basic FUNCTION
| inhibitor of WNT signaling |
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mediating interactions between epithelial and mesenchymal cells |
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playing a role in melanoma tumor progression |
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inhibitor of the Wnt/beta-catenin pathway  |
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immune modulator with a crucial role for CD8 T-cell tolerance  |
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role for DKK3 in down-regulating CD8 T-cell reactivity  |
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is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex  |
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DKK3 mediated regulation of spermatogenesis via WNT4/CTNNB1 modulation  |
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DKK1, DKK2, DKK3, DKK4 are known to modulate Wnt/CTNNB1 signaling, which is activated during bone formation  |
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is a novel modulator interfering with B cell fate as well as the maintenance program of B cells, leading to changes in B cell immune responses  |
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induces stem cell differentiation into smooth muscle lineage via ATF6 signalling  |
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DKK3 promotes cell survival during oxidative stress by suppressing the expression of the superoxide-producing enzyme XDH  |