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FLASH GENE
Symbol DIXDC1 contributors: - updated : 26-04-2006
HGNC name DIX domain containing 1
HGNC id 23695
Location 11q23.1      Physical location : 111.807.926 - 111.893.305
Synonym name coiled-coil-DIX1
Synonym symbol(s) KIAA1735, CCD1, MTHDIX
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text linked to DLAT gene in tail-to-head manner with an interval less than 4.0 kb
STRUCTURE 45.00 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
MGC50104 11q23.2 Similar to RIKEN cDNA 1810046K07 gene LOC120376 11q23.2 hypothetical protein LOC120376 POU2AF1 11q23.1 POU domain, class 2, associating factor 1 BTG4 11q23.2-q23.3 B-cell translocation gene 4 LOC387807 11 hypothetical gene supported by AK128145; BC039505 LOC143903 11q23.2 layilin SIK2 11q23.2 salt-inducible serine/threonine kinase 2 PPP2R1B 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform DIBD1 11q23 disrupted in bipolar affective disorder 1 C11orf1 11p15.5 chromosome 11 open reading frame 1 CRYAB 11q22.3-q23.1 crystallin, alpha B HSPB2 11q22.3-q23.1 heat shock 27kDa protein 2 MGC14839 11q23.2 similar to RIKEN cDNA 2310030G06 gene DIXDC1  DIX domain containing 1 LOC387808 11 similar to KIAA1735 protein DLAT 11q23.1 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) LOC246731 11q23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene LOC120379 11q23.2 hypothetical protein BC019238 FLJ10726 11q23.2 hypothetical protein FLJ10726 TIMM8B 11q23.1-q23.2 translocase of inner mitochondrial membrane 8 homolog B (yeast) SDHD 11q22.3-q23.1 succinate dehydrogenase complex, subunit D, integral membrane protein IL18 11q22.2-q22.3 interleukin 18 (interferon-gamma-inducing factor) TEX12 11q22 testis expressed sequence 12 BCDO2 11q22.3-q23.1 beta-carotene dioxygenase 2 MRPS36P4 11q23.2 mitochondrial ribosomal protein S36 pseudogene PTS 11q22.3-q23.3 6-pyruvoyltetrahydropterin synthase PLET1 11q23.2 placenta expressed transcript 1 LOC387809 11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein LOC387810 11 LOC387810
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebonesubchondral  
cell lineage
cell lines lung cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • myosine-tail homologous (MTH) domain
  • leucine zipper motif (codon 202-237) and another tyrosine phosphorylation site (Tyr 272)
  • a coiled-coil domain required for its inhibition of JNK
  • C-terminal DIX domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in Wnt signaling
  • play a role in the JNK cascades with DVL and axin, inhibiting c-Jun N-terminal kinase activation by axin and dishevelled 1
  • inhibiting Axin-mediated JNK activation by simultaneously adopting two distinct mechanisms, one through conformational changes that disallow MAP3K1 binding and the other via direct sequestration of MAP3K4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS