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FLASH GENE
Symbol DIXDC1 contributors: - updated : 26-04-2006
HGNC name DIX domain containing 1
HGNC id 23695
Location 11q23.1      Physical location : 111.807.926 - 111.893.305
Synonym name coiled-coil-DIX1
Synonym symbol(s) KIAA1735, CCD1, MTHDIX
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text linked to DLAT gene in tail-to-head manner with an interval less than 4.0 kb
STRUCTURE 45.00 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebonesubchondral  
cell lineage
cell lines lung cancer cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • myosine-tail homologous (MTH) domain
  • leucine zipper motif (codon 202-237) and another tyrosine phosphorylation site (Tyr 272)
  • a coiled-coil domain required for its inhibition of JNK
  • C-terminal DIX domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in Wnt signaling
  • play a role in the JNK cascades with DVL and axin, inhibiting c-Jun N-terminal kinase activation by axin and dishevelled 1
  • inhibiting Axin-mediated JNK activation by simultaneously adopting two distinct mechanisms, one through conformational changes that disallow MAP3K1 binding and the other via direct sequestration of MAP3K4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS