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FLASH GENE
Symbol DIS3L2 contributors: mct - updated : 08-07-2015
HGNC name DIS3 mitotic control homolog (S. cerevisiae)-like 2
HGNC id 28648
Corresponding disease
PRLMNS Perlman syndrome
Location 2q37.1      Physical location : 232.826.292 - 233.201.907
Synonym name
  • family with sequence similarity 6, member A
  • DIS3-like exonuclease 2
    • Synonym symbol(s) FAM6A, FLJ36974, MGC42174
    EC.number 3.1.13.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text duplication
    STRUCTURE 382.39 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3507 99.1 885 - 2012 22306653
    14 - 2481 - 603 - 2012 22306653
    7 - 1154 - 249 - 2012 22306653
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to DIS3, DIS3L
    Homologene
    FAMILY
  • FAM6 family
  • ribonuclease II (RNB) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • localizes in the cytoplasm and in cytoplasmic foci, which are docked to P-bodies
    • basic FUNCTION
  • has a different intracellular localization and lacks the PIN domain found in DIS3 and DIS3L1, but has exonuclease activity
  • has potentially a critical role in RNA metabolism and is essential for the regulation of cell growth and division
  • is potentially an important factor in mRNA degradation
  • role for DIS3L2 in the LIN28A-MIRLET7A1 pathway
  • DIS3L2 and XRN1 affect important cellular processes such as proliferation and apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PRLMNS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS