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FLASH GENE
Symbol DIS3 contributors: mct - updated : 08-07-2013
HGNC name DIS3 mitotic control homolog (S. cerevisiae)
HGNC id 20604
Location 13q22.1      Physical location : 73.329.541 - 73.356.344
Synonym name
  • related to S pombe mitotic control protein DIS3
  • mitotic control protein dis3 homolog
  • ribosomal RNA processing protein 44
  • exosome complex exonuclease RRP44
    • Synonym symbol(s) RRP44, dis3p, KIAA1008, FLJ10484, MGC33035, RP11-342J4.3, bA555G22.1, DKFZp667L1817
    EC.number 3.1.13.-
    DNA
    TYPE functioning gene
    STRUCTURE 26.80 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PCDH9 13q13.3 protocadherin 9 LOC390410 13 similar to 40S RIBOSOMAL PROTEIN SA (P40) (34/67 KD LAMININ RECEPTOR) LOC390411 13 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 OR7E33P 13q22.3 olfactory receptor, family 7, subfamily E, member 33 pseudogene LOC390412 13 hypothetical gene supported by BC050367 KLHL1 13q21 kelch-like 1 (Drosophila) DACH 13q21-q22 dachshund homolog (Drosophila) FLJ22624 13q21.33 FLJ22624 protein DIS3 13q21.33 FLJ22624 protein PIBF1 13q21.33 progesterone-induced blocking factor 1 LOC338091 13q21 proteasome 26S non-ATPase subunit 10 pseudogene KLF5 13q21.33 Kruppel-like factor 5 (intestinal) LOC387934 13 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) LOC122134 13q21.33 similar to MAP/microtubule affinity-regulating kinase 3 LOC387935 13 LOC387935 KLF12 13q22 Kruppel-like factor 12 LOC122145 13q21.33 suppressor of bimD6 homolog pseudogene LOC387936 13 hypothetical gene supported by AL133018 LOC387937 13 LOC387937 TBC1D4 13q22 TBC1 domain family, member 4 AK000009 Acrg embryonic lethality (mouse) minimal region ortholog UCHL3 13q22 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) LMO7 13q22 LIM domain only 7 KCTD12 13q21 potassium channel tetramerisation domain containing 12 BTF3L1 13q22 basic transcription factor 3, like 1 LOC341720 13q22.1 similar to immune-responsive gene 1 LOC390413 13 similar to 60S ribosomal protein L7 DHX9P 13q21 DEAH (Asp-Glu-Ala-His) box polypeptide 9 pseudogene CLN5 13q22 ceroid-lipofuscinosis, neuronal 5 FBXL3A 13q22 F-box and leucine-rich repeat protein 3A PAM 5q15 peptidylglycine alpha-amidating monooxygenase SCEL 13q22 sciellin LOC390414 13 similar to chromosome 15 open reading frame 2 FLJ30046 13q22.1 hypothetical protein FLJ30046 EDNRB 13q22 endothelin receptor type B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 7667 109 958 - 2007 17643380
    21 - 7577 - 928 - 2007 17643380
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveintestinelarge intestinecolon moderately
     stomach   moderately
    Lymphoid/Immunelymph node   predominantly
    Reproductivemale systemtestis  highly
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal PIN domain necessary and sufficient for association with the core exosome, indicating its dual function as a nuclease and structural element
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to S pombe mitotic control protein DIS3
    intraspecies paralog to DIS3L2, DIS3L
    Homologene
    FAMILY
  • ribonuclease II (RNB) family
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • exosome (RNase complex)
  • nuclear localization
    • basic FUNCTION
  • required for the 3' processing of the 7S pre-RNA to the mature nuclear complex
  • having a 3'-5' exonuclease activity
  • RNase activity of DIS3, a core subunit of exosome, was found to be required for proper kinetochore formation and establishment of kinetochore-microtubule interactions
  • contribute potentially to kinetochore formation through an involvement in heterochromatic silencing at both outer centromeric repeats and within the central core region
  • DIS3 and DIS3L are active exonucleases, but, only DIS3 has retained endonucleolytic activity
  • DIS3L2, DIS3 and DIS3L, have exoribonuclease activity and bind to the core RNA exosome complex
  • can processively digest structured RNA one nucleotide at a time in the 3prime to 5prime direction
  • accumulates the energy released by multiple single nucleotide step hydrolysis reactions until about four base pairs are unwound in a burst
  • ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species
  • required for the development of a multicellular organism
    • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide
    PHYSIOLOGICAL PROCESS
    text
  • rRNA processing
    • PATHWAY
    metabolism
    signaling
    a component
  • component of the exosome 3'->5' exoribonuclease complex
  • catalytic subunit of the exosome
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • GTPase Ran
  • association of DIS3 and DIS3L--with the human exosome core
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS