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FLASH GENE
Symbol DIS3 contributors: mct - updated : 08-07-2013
HGNC name DIS3 mitotic control homolog (S. cerevisiae)
HGNC id 20604
Location 13q22.1      Physical location : 73.329.541 - 73.356.344
Synonym name
  • related to S pombe mitotic control protein DIS3
  • mitotic control protein dis3 homolog
  • ribosomal RNA processing protein 44
  • exosome complex exonuclease RRP44
  • Synonym symbol(s) RRP44, dis3p, KIAA1008, FLJ10484, MGC33035, RP11-342J4.3, bA555G22.1, DKFZp667L1817
    EC.number 3.1.13.-
    DNA
    TYPE functioning gene
    STRUCTURE 26.80 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 7667 109 958 - 2007 17643380
    21 - 7577 - 928 - 2007 17643380
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveintestinelarge intestinecolon moderately
     stomach   moderately
    Lymphoid/Immunelymph node   predominantly
    Reproductivemale systemtestis  highly
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal PIN domain necessary and sufficient for association with the core exosome, indicating its dual function as a nuclease and structural element
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to S pombe mitotic control protein DIS3
    intraspecies paralog to DIS3L2, DIS3L
    Homologene
    FAMILY
  • ribonuclease II (RNB) family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • exosome (RNase complex)
  • nuclear localization
  • basic FUNCTION
  • required for the 3' processing of the 7S pre-RNA to the mature nuclear complex
  • having a 3'-5' exonuclease activity
  • RNase activity of DIS3, a core subunit of exosome, was found to be required for proper kinetochore formation and establishment of kinetochore-microtubule interactions
  • contribute potentially to kinetochore formation through an involvement in heterochromatic silencing at both outer centromeric repeats and within the central core region
  • DIS3 and DIS3L are active exonucleases, but, only DIS3 has retained endonucleolytic activity
  • DIS3L2, DIS3 and DIS3L, have exoribonuclease activity and bind to the core RNA exosome complex
  • can processively digest structured RNA one nucleotide at a time in the 3prime to 5prime direction
  • accumulates the energy released by multiple single nucleotide step hydrolysis reactions until about four base pairs are unwound in a burst
  • ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species
  • required for the development of a multicellular organism
  • CELLULAR PROCESS cell cycle, division, mitosis
    nucleotide
    PHYSIOLOGICAL PROCESS
    text
  • rRNA processing
  • PATHWAY
    metabolism
    signaling
    a component
  • component of the exosome 3'->5' exoribonuclease complex
  • catalytic subunit of the exosome
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • GTPase Ran
  • association of DIS3 and DIS3L--with the human exosome core
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS