basic FUNCTION
| required for the 3' processing of the 7S pre-RNA to the mature nuclear complex |
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having a 3'-5' exonuclease activity |
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RNase activity of DIS3, a core subunit of exosome, was found to be required for proper kinetochore formation and establishment of kinetochore-microtubule interactions  |
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contribute potentially to kinetochore formation through an involvement in heterochromatic silencing at both outer centromeric repeats and within the central core region  |
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DIS3 and DIS3L are active exonucleases, but, only DIS3 has retained endonucleolytic activity  |
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DIS3L2, DIS3 and DIS3L, have exoribonuclease activity and bind to the core RNA exosome complex  |
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can processively digest structured RNA one nucleotide at a time in the 3prime to 5prime direction  |
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accumulates the energy released by multiple single nucleotide step hydrolysis reactions until about four base pairs are unwound in a burst  |
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ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species  |
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required for the development of a multicellular organism  |