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FLASH GENE

Symbol

DIRC2

contributors: mct - updated : 22-01-2013

HGNC name	disrupted in renal carcinoma 2
HGNC id	16628

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q21.1      Physical location : 122.513.900 - 122.599.983
Synonym name	renal cell carcinoma 4
Synonym symbol(s)	FLJ14784, RCC4

DNA

TYPE	functioning gene
STRUCTURE	86.07 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - PASS1 - DIRC2 - SEMA5B - qter
Authors	Bodmer (02)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032839 9 - 3348 NP_116228 52 478 - 2011 21692750

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral lobe frontal   Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	N-terminal dileucine motif mediating lysosomal targeting
	large hydrophilic region
	twelve membrane spanning domains
	cytoplasmic N and C terminus
	conserved MFS specific signature

HOMOLOGY

intraspecies

homolog to FLVCR

Homologene

FAMILY

major facilitator superfamily (MFS) of transporter

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION

electrogenic lysosomal metabolite transporter which is subjected to and presumably modulated by limited proteolytic processing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS