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FLASH GENE
Symbol DIP2A contributors: mct/npt - updated : 04-05-2009
HGNC name DIP2 disco-interacting protein 2 homolog A (Drosophila)
HGNC id 17217
Location 21q22.3      Physical location : 47.878.861 - 47.989.926
Synonym name
  • human mRNA for KIAA0184 protein
  • disco-interacting protein 2 (Drosophila) homolog
  • chromosome 21 open reading frame 106
  • DIP2-like protein
    • Synonym symbol(s) KIAA0184, DIP2, C21orf106
    DNA
    TYPE functioning gene
    STRUCTURE 109.71 kb     38 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3606 119.3 1110 - Mukhopadhyay (2002)
    - - 2758 85.9 798 - Mukhopadhyay (2002)
    - - 7278 169.8 1567 - Mukhopadhyay (2002)
    38 - 7290 170.2 1571 - Mukhopadhyay (2002)
    18 - 3121 95.9 889 - Mukhopadhyay (2002)
    21 - 2887 90.5 841 - Mukhopadhyay (2002)
    20 - 2927 87.2 812 - Mukhopadhyay (2002)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestivestomach   highly
    Endocrinethyroid   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • crystallin beta gamma Greek key motif
    • HOMOLOGY
    Homologene
    FAMILY
  • DIP2 family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text present on the cell surface of endothelial cells (Ouchi 2010)
    basic FUNCTION
  • may be involved in axon patterning in the central nervous system
  • functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1 (Ouchi 2010)
  • involvement of DIP2A in FSTL1-mediated Akt signaling (Ouchi 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel FSTL1-binding partner from the membrane fraction of endothelial cells (Ouchi 2010)
  • receptor for FSTL1 that mediates AKT1 activation and cell survival and function in cardiovascular cells (Ouchi 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility for susceptibility to dyslexia (Poelmans 2009)
    Variant & Polymorphism
    Candidate gene for dyslexia (Poelmans 2009)
    Marker
    Therapy target
    ANIMAL & CELL MODELS