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FLASH GENE
Symbol DIO1 contributors: - updated : 24-08-2007
HGNC name deiodinase, iodothyronine, type I
HGNC id 2883
Location 1p33-p32      Physical location : 54.359.860 - 54.376.758
Synonym name
  • type-I 5'deiodinase
  • thyroxine deiodinase type I (selenoprotein)
  • Synonym symbol(s) 5DI, MGC130050, MGC130051, TXDI1
    EC.number 1.97.1.10
    DNA
    TYPE like-sequence
    STRUCTURE 16.00 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    KIAA1836 1p32.3 KIAA1836 protein ORC1L 1p32 origin recognition complex, subunit 1-like (yeast) FLJ14936 1p33-p32.1 hypothetical protein FLJ14936 KIAA0191 1p31-32 hypothetical protein FLJ14936 GPX6 6p21.33 glutathione peroxidase 6 (olfactory) MGC52498 1p32.3 hypothetical protein MGC52498 FLJ12439 1p32.3 hypothetical protein FLJ12439 FLJ13456 1p32.3 hypothetical protein FLJ13456 FLJ10948 1p32.3 hypothetical protein FLJ10948 SCP2 1p32 sterol carrier protein 2 PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor FLJ40434 1p32.3 hypothetical protein FLJ40434 DMRTB1 1p33 DMRT-like family B with proline-rich C-terminal, 1 FLJ36155 1p32.3 likely ortholog of mouse Gli-similar 1 Kruppel-like zinc finger (Glis1) FLJ10407 1p32.3 hypothetical protein FLJ10407 DJ167A19.1 1p33-p32.1 hypothetical protein DJ167A19.1 DIO1 1p32-p33 deiodinase, iodothyronine, type I LOC51668 1p32.1-p33 HSPCO34 protein MGC8974 1p33-p32.1 hypothetical protein MGC8974 LOC388632 1 similar to heterogeneous nuclear ribonucleoprotein A3 LOC388633 1 similar to Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330) C1orf8 1p36-p31 chromosome 1 open reading frame 8 FLJ32112 1p32.3 hypothetical protein FLJ32112 LOC343190 LOC200008 1p32.3 hypothetical protein LOC200008 MRPL37 1p32.1 mitochondrial ribosomal protein L37 SSBP3 1p31.3 single stranded DNA binding protein 3 LOC391041 1 hypothetical gene supported by BC004945 THEA 1p31.3 thioesterase, adipose associated MGC27169  hyporthetical protein MGC27169 TTC4 1p31.3 tetratricopeptide repeat domain 4 DKFZp727A071 1p32.2 similar to tRNA synthetase class II FLJ20619 1p32.3 hypothetical protein FLJ20619 FLJ40201 1p32.3 hypothetical protein FLJ40201 DHCR24 1p32 24-dehydrocholesterol reductase LOC199964 1p32.3 hypothetical protein LOC199964 BSND 1p31 hypothetical protein LOC199964 PCSK9 1p32.3 proprotein convertase subtilisin/kexin type 9 USP24 1p32.2-p31.2 ubiquitin specific protease 24 LOC388634 1 similar to Ubiquitin carboxyl-terminal hydrolase 24 (Ubiquitin thiolesterase 24) (Ubiquitin-specific processing protease 24) (Deubiquitinating enzyme 24) LOC388635 1 LOC388635 LOC391042 1 similar to glycogenin LOC391043 1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1876 - 249 - de Jong
    - - 1684 - 185 - de Jong
    - - 1732 - 201 - de Jong
    - - 1676 - 161 - de Jong
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinethyroid   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a selenocysteine at position 382
  • HOMOLOGY
    interspecies homolog to rat Dio1 (88p100)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in inappropriate thyroid-stimulating hormone secretion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    thyroid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in benign and malignant thyroid tumors
    tumoral     --low  
    in nearly all papillary thyroid carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target useful as potential targets for thyroid tumor treatment
    ANIMAL & CELL MODELS