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FLASH GENE
Symbol DIMT1 contributors: mct - updated : 06-11-2019
HGNC name DIMT1 rRNA methyltransferase and ribosome maturation factor
HGNC id 30217
Location 5q12.1      Physical location : -
Synonym name
  • putative dimethyladenosine transferase
  • DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
  • Synonym symbol(s) HSA9761, DIM1L, HSA9761, HUSSY5, DIMT1L
    EC.number 2.1.1.-/2.1.1.183
    DNA
    TYPE functioning gene
    STRUCTURE 16.65 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2831 - 313 - 2017 28601661
    12 - 2913 - 160 - 2017 28601661
    11 - 1213 - 275 - 2017 28601661
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   predominantly
    Nervousnerve   moderately
    Reproductivefemale systemplacenta  highly
     male systemprostate  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY rRNA adenine N-6-methyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • dimethylating two adjacent adenosines in the loop of a conserved hairpin near the 3'end of 16s rRNA in the 30s particle
  • DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    rRNA processing, rRNA modification
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated closely with differentiation, invasion, lymph node metastasis, distant metastasis in gastric carcinoma
    tumoral     --over  
    gradually with multiple myeloma progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a useful molecular biomarker to predict tumor progression and prognosis in patients with gastric carcinoma (28601661)
  • is a novel diagnostic marker for all molecular subtypes of multiple myeloma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic target for all molecular subtypes of multiple myeloma
    ANIMAL & CELL MODELS