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FLASH GENE
Symbol DIDO1 contributors: mct - updated : 06-12-2014
HGNC name death inducer-obliterator 1
HGNC id 2680
Location 20q13.33      Physical location : 61.509.089 - 61.569.304
Synonym name
  • death associated transcription factor 1
  • chromosome 20 open reading frame 158
  • bypass of Ess1
  • Synonym symbol(s) BYE1, C20orf158, DATF1, DIDO2, DIDO3, DIO-1, DIO1, KIAA0333, ESS1
    DNA
    TYPE functioning gene
    STRUCTURE 60.21 kb     16 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same isoform (a)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 2837 61.2 562 - 2007 17299043
  • alternative exon 1 compared to variant 2
  • 6 splicing 2800 61.2 562 - 2007 17299043
  • shortest transcript
  • alternative exon 1 compared to variant 1
  • 15 splicing 7657 129.1 1189 - 2007 17299043
  • utilizing multiple additional 3' coding exons
  • having a unique C terminus
  • 16 splicing 8592 243.7 2240 centrosome 2007 17299043
  • DIDO3
  • longest transcript and encodes the longest isoform
  • centrosome-associated protein whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint protein BUB1B
  • implicated in the maintenance of stem cell genomic stability and tumorigenesis
  • histone H3 lysine 4 demethylation modulates DIDO3 localization in meiosis and suggest epigenetic regulation of the synaptonemal complex
  • 16 - 8548 - 2240 - 2007 17299043
    15 - 7613 129.2 1189 - 2007 17299043
  • DIDO2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     mouth   moderately
    Lymphoid/Immunelymph node   moderately
     spleen   moderately
     thymus   highly
     tonsils   moderately
    Nervousbrain    
     nervecranial nerve  moderately
    Reproductivefemale systemuteruscervix moderately
     female systemovary  moderately
     male systemtestis  moderately
    Respiratoryrespiratory tractlarynx  moderately
    Urinarybladder   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoietic    
    Lymphoid    
    Muscular   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal plant homeo domain (PHD) (residues 74134), contributing to chromatin association by binding trimethylated H3K4 peptides
  • a zinc finger motif
  • two nuclear localization signals (NLS)
  • transcriptional activation domain
  • central TFIIS-like domain (TLD, residues 232365), important for the association with chromatin
  • C-terminal Spen paralogue and orthologue C-terminal (SPOC) domain (residues 447547), implicated in developmental signaling
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Datf (76.4 pc)
    homolog to murine Dido (75.9 pc)
    homolog to yeast Bye1
    intraspecies homolog to KIAA0244
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • translocated to the nucleus after pro-apoptotic stimuli
  • localizes to the nucleus
  • basic FUNCTION
  • triggering apoptosis
  • involved in regulation of transcription, DNA dependent
  • involved in onset of apoptosis where misexpression disrupts limb development
  • its malfunction is reported to be part of an impaired signaling cascade that results in a defective mitotic checkpoint, leading to chromosome instability
  • induces the expression of ITGA5, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells
  • is the founding member of a unique family of chromatin transcription factors that link histones with active posttranslational modifications (PTMs) to transcribing Pol II
  • plays an important role in regulating ES cell maintenance.
  • once Pol II is engaged into elongation, PHF3 and DIDO1 binds directly to the transcriptional machinery, modulating its progression along the gene
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • BMP-specific SMAD-regulated target gene
  • binds to early Pol II elongation complexes at the beginning of transcribed regions of active genes without changing polymerase structure or function
  • could target to the loci of pluripotency factors such as NANOG and POU5F1 and positively regulate their expression
  • cell & other
    REGULATION
    inhibited by caspase inhibitors and BCL2 overexpression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    altered expression implicated in the induction of hematological myeloid neoplasms
    tumoral     --over  
    in melanoma cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • targeted disruption causes a transplantable myelodysplastic/myeloproliferative disease in mice (Trachana (07)
  • specific ablation of Dido3 function in mice causes lethal developmental defects at the onset of gastrulation