basic FUNCTION
| play an essential role in mammalian siRNA-mediated posttranscriptional gene silencing ( |
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involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway |
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producing 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs |
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acting as an endonuclease |
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playing a critical role in maintaining the proliferating pool of chondrocytes through regulation of chondrocyte proliferation and inhibition of premature differentiation to postmitotic hypertrophic chondrocytes |
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required for maintenance of proliferating chondrocytes in the growth plate |
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playing an essential role in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions |
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also involved in the assembly of the RNA-induced silencing complex (RISC) that mediates the effector steps of RNA silencing |
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essential for turnover of a substantial subset of maternal transcripts that are normally lost during oocyte maturation and as central to a regulatory network that controls oocyte gene expression programs and that promotes genomic integrity in a cell type notoriously susceptible to aneuploidy ( |
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miRNA processing enzyme that are required for the maturation of miRNAs |
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significantly increased the expression of thrombospondin-1 |
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transient reduction of the miRNA-regulating enzyme Dicer impairs angiogenesis |
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essential roles for Dicer in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions ( |
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prevalent role of DICER1 and EIF2C4 in neural cell differentiation |
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may be an important haploinsufficient tumor suppressor gene |
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plays a crucial role in melanocyte survival involving, in part, posttranscriptional processing of miR-17 which leads to downregulation of the proapoptotic protein BCL2L11 |
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ribonuclease playing a key role in the biogenesis of microRNAs and small interfering RNAs |
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key role of DICER1 in maintaining retinal pigmented epithelium (RPE) cell health |
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cellular functions dependent on DICER expression are not required for the early steps in CD8+ T-cell activation, but are essential for their survival and accumulation |
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essential for the CD8+ effector T-cell response |
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DICER1/miRNAs also control CD8+ T-cell activation, proliferation, migration, and accumulation during acute infection |
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regulates CD8+ T-cell activation and proliferation, and controls CD69 retention and cell migration in activated CD8+ T cells |
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key mediator of miRNA biosynthesis, within the optic cup in overlapping yet distinct spatiotemporal patterns |
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required for vascular development and regulates vascular remodeling by modulating VSMC (vascular smooth muscle cells) proliferation and differentiation |
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key regulator in siRNA and miRNA biogenesis |
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essential during early retinal development ( |
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DDX3X and DICER1 are also required in promoting chromosome segregation and chromosomal localization of NCAPH (human homolog of Barr) |
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accurate processing by DICER1 is crucial for the functionality of microRNAs (miRNAs) |
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appears to be the first gene implicated in the etiology of cervix embryonal rhabdomyosarcoma (cERMS), and primitive neuroectodermal tumor (cPNE) |
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multiple functions for DROSHA and DICER1 in suppressing DNA damage in rapidly proliferating follicular matrix cells, facilitating catagen and maintaining follicular structures and their associated stem cells |
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rate-limiting enzyme for microRNA (miRNA) synthesis |
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controls proadipogenic genes such as CEBPA and PPARG in the early, but not in the late, stage of adipogenesis via regulation of miRNA synthesis |
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is an essential endogenous negative regulator of NLRP3 inflammasome activation, and its deficiency leads to Alu RNA-mediated, MYD88-dependent, microRNA-independent RPE degeneration |
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required for the biogenesis of several small RNA species |
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DICER1 and DROSHA RNA products control DNA-damage response (DDR) activation and act independently from canonical microRNA-mediated translational repression mechanisms |
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is a critical regulator of post-transcriptional gene silencing |
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hypoxic down-regulation of DICER1 plays a significant role in maintaining the cellular response to hypoxia by preserving the expression of HIF1A and HIF2A via microRNA regulation |
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cytoplasmic RISC proteins PRKRA, TARBP2, and DICER1 are steroid receptor RNA activator (SRA) binding nuclear receptor (NR) coregulators that target steroid-responsive promoters and regulate NR activity and downstream gene expression |