basic FUNCTION
| forming a matrix of keratin intermediate filaments which contribute to the structure of hair fibers |
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involved in transcription and RNA processing |
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plays a role in promoting the DNA processing function of WRN, which in turn might be necessary for maintaining genomic stability |
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involved in multiple cellular processes and the life cycles of many viruses  |
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essential for survival of cultured hepatoma cells and the ATPase activity appears to be important for this critical role  |
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acting as a bridging factor linking nuclear beta-actin with Pol II  |
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substrate for EIF2AK2, with phosphorylation perturbing the association of the helicase with double-stranded RNA (dsRNA)  |
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cooperative functions for WRN and DHX9 at both migrating and stalled replication forks, where they seem to be involved in the removal of primer RNA-containing Okazaki fragments  |
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role in maintaining genome integrity by unwinding mutagenic triplex DNA structures  |
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possesses strand displacement activity on triplex DNA structures containing a 3prime-single-stranded overhang, but undetectable activity on the blunt-end duplex DNA structures  |
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having ability to preferentially resolve mutagenic triplex DNA structures in an ATP-dependent fashion  |
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DDX3X, DDX1 and DHX9 are among the helicases that are required for the replication of a diverse range of viruses  |