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FLASH GENE
Symbol DHX9 contributors: mct/ - updated : 25-01-2010
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 9
HGNC id 2750
Location 1q25.3      Physical location : 182.808.438 - 182.857.115
Synonym name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II; leukophysin)
  • leukophysin
  • ATP-dependent RNA helicase A
  • nuclear DNA helicase II
    • Synonym symbol(s) LKP, RHA, DDX9, NDHII, NDH II, NDH2
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 48.68 kb     28 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 4543 - 1270 - 2009 19229320
    full length
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven conserved core motifs, including two copies of a double-stranded RNA-binding domain at the N-terminus
  • a RGG box, forming a protein-protein interaction surface that contacts the exonuclease domain of WRN
  • nuclear localization signal(RHA-NLS) consisting of 19 AAs is highly conserved through species
  • a bidirectional nuclear transport domain (NTD) located in its C- terminus and a RGG rich region
    • HOMOLOGY
    interspecies homolog to Drosophila maleless (MLE)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEXH family of helicase superfamily 2
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • its translocation from the nucleolus to the nucleus found with IMPDH inhibition does not mediate the inhibition of rRNA synthesis
  • shuttles rapidly between the nucleus and the cytoplasm by virtue of a bidirectional nuclear transport domain (NTD) located in its carboxyl terminus
    • basic FUNCTION
  • forming a matrix of keratin intermediate filaments which contribute to the structure of hair fibers
  • involved in transcription and RNA processing
  • plays a role in promoting the DNA processing function of WRN, which in turn might be necessary for maintaining genomic stability
  • involved in multiple cellular processes and the life cycles of many viruses
  • essential for survival of cultured hepatoma cells and the ATPase activity appears to be important for this critical role
  • acting as a bridging factor linking nuclear beta-actin with Pol II
  • substrate for EIF2AK2, with phosphorylation perturbing the association of the helicase with double-stranded RNA (dsRNA)
  • cooperative functions for WRN and DHX9 at both migrating and stalled replication forks, where they seem to be involved in the removal of primer RNA-containing Okazaki fragments
  • role in maintaining genome integrity by unwinding mutagenic triplex DNA structures
  • possesses strand displacement activity on triplex DNA structures containing a 3prime-single-stranded overhang, but undetectable activity on the blunt-end duplex DNA structures
  • having ability to preferentially resolve mutagenic triplex DNA structures in an ATP-dependent fashion
  • DDX3X, DDX1 and DHX9 are among the helicases that are required for the replication of a diverse range of viruses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the triplex DNA-protein complex in mammalian cells
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds MBD2, HRMT1L2/PRMT1, and RELA
  • interact with XRCC5 and with TOP2A in an RNA dependent
    • manner
  • interacts with the Werner syndrome helicase WRN, an enzyme associated with premature aging and predisposition to tumorigenesis, DNA helicase (WRN) that can engage in direct protein–protein interactions with DHX9, an essential enzyme involved in transcription and DNA repair
  • actin-interacting protein in pre-initiation complexes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS