basic FUNCTION
| functioning as a negative regulator of host defense (Saito 2007) |
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cytosolic pattern recognition receptor detecting single-stranded or double-stranded RNA in virally infected cells (Li 2009) |
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differentially regulates DHX58- and IFIH1-dependent RNA sensing in an unknown manner (Pippig 2009) |
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regulates the signaling of the DDX58-like receptors |
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required for signaling, and plays an important role in modulating signaling by IFIH1 and DDX58, presumably through heterocomplex formation and/or by serving as a sink for RNAs (Murali 2008) |
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has striking structural similarity to the helicase domain of the superfamily 2 DNA helicase, HEF (Murali 2008) |
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RD modulates RIG-I-dependent signaling via competition for dsRNA, another pattern sensed by RIG-I, while a fully functional LGP2 is required to augment MDA5-dependent signaling |
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facilitates viral RNA recognition by DDX58 and IFIH1 through its ATPase domain (Satoh 2010) |