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FLASH GENE
Symbol DHX58 contributors: mct/npt - updated : 22-06-2016
HGNC name DEXH (Asp-Glu-X-His) box polypeptide 58
HGNC id 29517
Location 17q21.2      Physical location : 40.253.421 - 40.264.751
Synonym name
  • likely ortholog of mouse D11lgp2
  • RNA helicase LGP2
  • protein D11Lgp2 homolog
  • RIG-I like receptor
  • probable ATP- dependent helicase LGP2
  • RIG-I-like receptor LGP2
  • Synonym symbol(s) LGP2, D11LGP2, D11LGP2E, RLR, RLR-1
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 11.33 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2631 76 678 - Li (2009)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreast   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    cell lineage
    cell lines neoplastic mammary cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two conserved domains DEAD/H (Asp-Glu-Ala-Asp/His)
  • a zinc-binding domain structurally related to GDP/GTP exchange factors of Rab-like GTPases (Cui 2008)
  • a helicase C terminal domain, responsible for RNA binding (Li 2009), and regulatory domain modulating DDX58-dependent signaling via competition for dsRNA, another pattern sensed by DDX58, while a fully functional DHX58 is required to augment IFIH1-dependent signaling (Pipig 2009)
  • HOMOLOGY
    interspecies homolog to murine Lgp2
    intraspecies homolog to DDX58, IFIH1
    Homologene
    FAMILY
  • helicase family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning as a negative regulator of host defense (Saito 2007)
  • cytosolic pattern recognition receptor detecting single-stranded or double-stranded RNA in virally infected cells (Li 2009)
  • differentially regulates DHX58- and IFIH1-dependent RNA sensing in an unknown manner (Pippig 2009)
  • regulates the signaling of the DDX58-like receptors
  • required for signaling, and plays an important role in modulating signaling by IFIH1 and DDX58, presumably through heterocomplex formation and/or by serving as a sink for RNAs (Murali 2008)
  • has striking structural similarity to the helicase domain of the superfamily 2 DNA helicase, HEF (Murali 2008)
  • RD modulates RIG-I-dependent signaling via competition for dsRNA, another pattern sensed by RIG-I, while a fully functional LGP2 is required to augment MDA5-dependent signaling
  • facilitates viral RNA recognition by DDX58 and IFIH1 through its ATPase domain (Satoh 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PUM1, PUM2 increased double-stranded (ds) RNA binding affinity of DHX58, and likely facilitates viral RNA recognition by DHX58 through its chaperon-like function
  • MAVS plays a key role in the signal transduction of DHX58-mediated antiviral response
  • ZYX serves as a scaffold for the interactions between DHX58 and MAVS
  • BST2 is a negative regulator of DHX58-mediated type I IFN signaling by targeting MAVS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS