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FLASH GENE
Symbol DHX33 contributors: mct - updated : 31-10-2015
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 33
HGNC id 16718
Location 17p13.2      Physical location : 5.345.593 - 5.372.181
Synonym symbol(s) FLJ21972, DDX33
EC.number 3.6.4.13
DNA
TYPE functioning gene
STRUCTURE 28.15 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 5474 - 534 - 2011 21930779
12 - 5635 - 707 - 2011 21930779
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one S1 motif
  • DEAD/H box (Asp - Glu - Ala - Asp/His)
  • C terminal RNA helicase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • mediating the release of the spliced mrna from spliceosomes
  • important modulator of 47S rRNA transcription
  • cell cycle-regulated nucleolar protein that associates with ribosomal DNA (rDNA) loci, where it interacts with the RNA Pol I transcription factor upstream binding factor (UBF)
  • crucial player in establishing rRNA synthesis rates in the face of RAS or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals
  • double-stranded RNA (dsRNA) sensor in myeloid dendritic cells
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, recombination
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    APT
    protein
  • is a cytosolic RNA sensor that activates the NLRP3 inflammasome
  • RNA helicase DHX33 binds to cytosolic dsRNAs to trigger NLRP3 inflammasome activation
  • interaction between the helicase DHX33 and MAVS (interaction between DHX33 and MAVS is mediated by the HELICc region of DHX33 and the C-terminal domain of MAVS)
  • ubiquitination of DHX33 by TRIM33 is lysine 63 specific and is required for the formation of the DHX33-NLRP3 inflammasome complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS