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FLASH GENE
Symbol DHX29 contributors: mct/npt - updated : 24-02-2010
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 29
HGNC id 15815
Location 5q11.2      Physical location : 54.552.073 - 54.603.521
Synonym name
  • nucleic acid helicase DDXx
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29
  • Synonym symbol(s) DDX29
    DNA
    TYPE functioning gene
    STRUCTURE 51.45 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 4491 - 1369 - Pisareva (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • helicase associated region, DEAD/DEAH box helicase motif
  • HOMOLOGY
    interspecies homolog to murine Dhx29
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • ATP-dependent RNA helicase activity
  • involved in translation initiation on mammalian mRNAs with structured 5prime UTRs (Pisareva 2008)
  • DExH-box protein, facilitating translation initiation on mRNAs with structured 5prime untranslated regions (Stevenson 2008)
  • translation initiation factor, required for cell proliferation, that potentially can be exploited as a target to inhibit cancer cell growth (Parsyan 2009)
  • cytoplasmic protein that associates with the 40S ribosomal subunit (Parsyan 2009)
  • plays a prominent role in the translation of mRNAs with highly structured 5prime UTRs (Parsyan 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
  • ATP binding
  • protein
  • binds 40S subunits and hydrolyzes ATP, GTP, UTP, and CTP (Pisareva 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    caused dissociation of polysomes, with a concomitant increase in the abundance of 80S ribosomes as well as 40S and 60S subunits (Parsyan 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target translational inhibition through DHX29 silencing might present a means by which cancer cell growth could be inhibited (Parsyan 2009)
    ANIMAL & CELL MODELS