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FLASH GENE
Symbol DHX15 contributors: mct/npt - updated : 30-10-2017
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 15
HGNC id 2738
Location 4p15.2      Physical location : 24.529.088 - 24.586.184
Synonym name
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15
  • DEAD/H box-15
  • RNA helicase 2
  • ATP-dependent RNA helicase
  • 46
    Synonym symbol(s) DBP1, HRH2, DDX15, PRP43, PRPF43, PrPp43p, DBP1,
    EC.number EC 3.6.4.13
    DNA
    TYPE functioning gene
    STRUCTURE 57.10 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SLIT2 4p15.2 slit homolog 2 (Drosophila) MGC29898 4p15.32 hypothetical protein MGC29898 KCNIP4 4p15.32 Kv channel interacting protein 4 FLJ30194 4p15.32 hypothetical protein FLJ30194 GPR125 4p15.32-p15.31 G protein-coupled receptor 125 GBA3 4p15.31 glucosidase, beta, acid 3 (cytosolic) PPARGC1 4p15.1 peroxisome proliferative activated receptor, gamma, coactivator 1 DHX15 4p15.3 DEAH (Asp-Glu-Ala-His) box polypeptide 15 LOC391640 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) SOD3 4p16.3-q21 superoxide dismutase 3, extracellular DKFZp761B107 4p15.31 hypothetical protein DKFZp761B107 LGI2 4p15.31 leucine-rich repeat LGI family, member 2 SLA/LP 4p15.31 soluble liver antigen/liver pancreas antigen PI4K2B 4p15.31 phosphatidylinositol 4-kinase type-II beta ANAPC4 4p15.31 anaphase-promoting complex subunit 4 LOC345348 4p15.31 similar to D-myo-inositol-3-phosphate synthase LOC391641 4 similar to chloroquine resistance marker protein SLC34A2 4p15.3-p15.1 solute carrier family 34 (sodium phosphate), member 2 KIAA0746 4p15.2 solute carrier family 34 (sodium phosphate), member 2 LOC389203 4 hypothetical gene supported by BC032431 RBPSUH 9p13-p12 recombining binding protein suppressor of hairless (Drosophila) CCKAR 4p15.2-p15.1 cholecystokinin A receptor FLJ11082 4p15.31 hypothetical protein FLJ11082 STIM2 4p15.2 stromal interaction molecule 2 LOC389204 4 LOC389204 MRPL51P1 4p15.2 LOC389204 LOC391642 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) LOC285509 4p15.2 hypothetical LOC285509 LOC391643 4 similar to mesoderm specific transcript isoform a; paternally expressed gene 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3019 - 795 - 2017 28115624
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunethymus   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DEAD/H box (Asp-Glu-Ala-His)
  • N terminal RGD motif,an Arg-Asp repeat (RD) RNA binding motif
  • N terminal helicase domain, and N-terminal domain containing a DEXDc motif bound the C terminus of MAVS
  • C terminal helicase associated domain
  • HOMOLOGY
    interspecies ortholog to yeast Prp43
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • DDX15/PRP43 sub-subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • DEAH-box RNA-dependent ATPase that catalyzes the release of excised lariat intron from the mRNA spliceosome
  • putative ATP-dependent RNA helicase implicated in pre-mRNA splicing
  • in cooperation with TFIP11 mediates the transition from the intron large complex to the intron small complex, leading to efficient debranching and turnover of excised introns (Yoshimoto 2009)
  • DHX15 activates NFKB1 and MAPK signaling downstream of MAVS during antiviral responses
  • is a new RNA virus sensor mediated by MAVS to activate the immune responses to RNA
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text preRNA splicing
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SSB (may be colocalized in the nucleoli)
  • interacting with TFIP11 (protein component of the spliceosome complex that promotes the release of the lariat-intron during late-stage splicing through a direct recruitment and interaction with DHX15) (Tannukit 2009)
  • DHX15 and PRPF19, two spliceosome components, are novel RBM5-interacting partner
  • DHX15 physically interacted with MAVS and mediated the MAVS-dependent activation of the NFKB1 and MAPK pathways
  • NLRP6 functions with DHX15 as a viral RNA sensor to induce IFN-stimulated genes (ISGs), and this effect is especially important in the intestinal tract
  • NKRF mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis
  • DHX15 regulates AR activity by modulating E3 ligase SIAH2-mediated AR ubiquitination independent of its ATPase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS