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FLASH GENE
Symbol DHRS9 contributors: mct - updated : 01-06-2007
HGNC name dehydrogenase/reductase (SDR family) member 9
HGNC id 16888
Location 2q31.1      Physical location : 169.921.298 - 169.952.679
Synonym name
  • 3-alpha hydroxysteroid dehydrogenase
  • NADP-dependent retinol dehydrogenase/reductase
  • short chain dehydrogenase/reductase family 9C, member 4
  • Synonym symbol(s) RETSDR8, RDHL, 3alpha-HSD, RDH15, RDHTBE, RETSDR8
    DNA
    TYPE functioning gene
    STRUCTURE 31.00 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    CMYA3 2q31.1 cardiomyopathy associated 3 LOC90643 2q31.1 similar to Meningioma-expressed antigen 6/11 (MEA6) (MEA11) B3GALT1 2q24.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 STK39 2q24.3 serine threonine kinase 39 (STE20/SPS1 homolog, yeast) LOC253782 2q31.1 hypothetical protein LOC253782 NOSTRIN 2q31.1 nitric oxide synthase trafficker AD024 IGRP 2q24-q31 nitric oxide synthase trafficker ABCB11 2q24.1 ATP-binding cassette, sub-family B (MDR/TAP), member 11 DHRS9 2q31.1 dehydrogenase/reductase (SDR family) member 9 LRP2 2q31-q32.1 low density lipoprotein-related protein 2 DKFZp762I194 2q31.1 hypothetical protein DKFZp762I194 SARCOSIN 2q31.1 hypothetical protein DKFZp762I194 FLJ21901 2q31 hypothetical protein FLJ21901 PPIG 2q31.1 peptidyl-prolyl isomerase G (cyclophilin G) LOC129881 2q31.1 hypothetical LOC129881 MGC22679 2q31.1 hypothetical protein MGC22679 LOC389057 2 similar to hypothetical protein MGC22679 AF357534 2q31.1 thioredoxin 1 pseudogene 7 LOC391459 2 LOC391459 SSB 2q31.1 Sjogren syndrome antigen B (autoantigen LA) HSPC133 2q31.1 HSPC133 protein LOC344287 2q31.1 similar to hypothetical protein A130030D10 KIAA2024 2q31.1 similar to F10G7.10.p MYO3B 2q31.1-q31.2 myosin IIIB LOC389058 2 similar to zinc finger protein Sp5 LOC285140 2q31.1 eukaryotic translation initiation factor 2 beta-like pseudogene LOC389059 2 LOC389059 LOC285141 2q31.1 similar to CG14853-PB GAD1 2q31 glutamate decarboxylase 1 (brain, 67kDa) GORASP2 2p24.3-q21.3 golgi reassembly stacking protein 2, 55kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2939 35 319 - -
    - - 1993 35 319 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine  highly
     mouthtongue   
     pharynx   highly
    Nervousbrain    
     spinal cord    
    Reproductivemale systemtestis   
    Respiratorylung    
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    four motifs conserved in the short chain (SDR) family of proteins
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY SDR family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • critical role in retinal metabolism in airway epithelia as well as in other epithelia of colon, tongue, esophagus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein expression regulated by APC and CDX2
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in Burkitt lymphoma and in T-cell acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS