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FLASH GENE
Symbol DHRS7 contributors: - updated : 15-06-2006
HGNC name dehydrogenase/reductase (SDR family) member 7
HGNC id 21524
Location 14q23.1      Physical location : 60.611.501 - 60.632.211
Synonym name
  • CGI-86 protein
  • retinal short-chain dehydrogenase/reductase 4
  • Synonym symbol(s) retDSR4, retSDR4, CGI-86
    EC.number 1.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing leading to two distinct proteins (289 aa or 339 aa)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     pharynx   moderately
    Endocrineparathyroid   predominantly
    Hearing/Equilibriumear   moderately
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Skin/Tegumentskin    
    Urinarykidney   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Epithelial    
    Muscular   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 28 aa signal peptide
  • SDR motif
  • isoforms Precursor a 311 aa mature peptide
    HOMOLOGY
    interspecies homolog to murine Dhrs7 (77.8pc)
    homolog to chicken DHRS7 (69.5pc)
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as an oxidoreductase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NAD
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS