Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DHRS4 contributors: mct - updated : 23-05-2011
HGNC name dehydrogenase/reductase (SDR family) member 4
HGNC id 16985
Location 14q11.2      Physical location : 24.422.964 - 24.438.486
Synonym name
  • NADP-dependent retinol dehydrogenase
  • peroxisomal short-chain alcohol dehydrogenase
  • NADPH-dependent retinol dehydrogenase/reductase
  • Synonym symbol(s) SCAD-SRL, SDR-SRL, humNRDR, FLJ11008
    EC.number 1.1.1.184
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text cluster consisting of DHRS4 and its copy gene DHRS4L2, DHRS4L1
    STRUCTURE 15.52 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BRD7P 14q11.2 bromodomain containing 7 pseudogene LOC390462 14 similar to peroxisomal short-chain alcohol dehydrogenase; NADP-dependent retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase DHRS4 14q11.2-14q21.3 dehydrogenase/reductase (SDR family) member 4 DHRS4L2 14 dehydrogenase/reductase (SDR family) member 4 like 2 LOC387975 14 similar to peroxisomal short-chain alcohol dehydrogenase; NADP-dependent retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase LOC90668 14q11.2 hypothetical protein BC008134 CPNE6 14q11.2 copine VI (neuronal) NRL 14q11.1-q11.2 neural retina leucine zipper PCK2 14q11.2-q12 phosphoenolpyruvate carboxykinase 2 (mitochondrial) WDR23 14q11.2 WD repeat domain 23 LOC161247 14q11.2 similar to 1110028A07Rik protein PSME1 14q11.2 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) C14orf122 14q11.2 chromosome 14 open reading frame 122 PSME2 14q11.2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) RNF31 14q11.2 ring finger protein 31 ISGF3G 14q11.2 interferon-stimulated transcription factor 3, gamma 48kDa REC8L1 14q11.2-q12 REC8-like 1 (yeast) IPO4 14q11.2 importin 4 TM9SF1 14q11.2 transmembrane 9 superfamily member 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1289 27 278 - 2009 18754758
    EXPRESSION
    Rna function
  • mRNA for the enzyme was ubiquitously expressed in human tissues and several cancer cells
  • Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    SDR motif
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine Dhrs4
    Homologene
    FAMILY short chain dehydrogenase/reductase (SDR) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,nucleus
    basic FUNCTION
  • reduces all trans-retinal and 9-cis-retinal
  • can catalyze the oxidation of trans-retinol with NADP as cofactor
  • reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings
  • may inhibit cell replication either by catalyzing the oxidation of estrogen and androgen, or by converting cortisone in cortisol
  • NADP(H)-dependent retinol oxidoreductase participating in the metabolism of retinoids
  • reduced various aromatic ketones and alpha-dicarbonyl compounds including cytotoxic 9,10-phenanthrenequinone (
  • role of the inducible DHRS4 in 3beta-hydroxysteroid synthesis and xenobiotic carbonyl metabolism
  • reduces all-trans-retinal and xenobiotic carbonyl compounds
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by kaempferol, quercetin, genistein and myristic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS