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FLASH GENE
Symbol DHRS2 contributors: mct - updated : 10-11-2010
HGNC name dehydrogenase/reductase (SDR family) member 2
HGNC id 18349
Location 14q11.2      Physical location : 24.105.572 - 24.114.846
Synonym name
  • short chain dehydrogenase/reductase family 25C, member 1
  • dicarbonyl reductase HEP27
  • protein D
  • Synonym symbol(s) HEP27, SDR25C1
    EC.number 1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 9.28 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    alternative promoter
    Binding site
    text structure
  • binding sites for ETS and OCT1
  • two alternative promoters: one hepatocyte specific and a second active in monocyte derived dendritic cells
  • MAPPING cloned Y linked N status provisional
    Physical map
    LOC122706 14q11.2 similar to RIKEN cDNA 5830406J20 CDH24 14q11.2 cadherin-like 24 ACINUS 14q11.2 apoptotic chromatin condensation inducer in the nucleus C14orf119 14q11.2 chromosome 14 open reading frame 119 CEBPE 14q11.2 CCAAT/enhancer binding protein (C/EBP), epsilon SLC7A8 14q11.2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 RPL39P2 14 ribosomal protein L39 pseudogene 2 HMGN2P 14 high-mobility group nucleosomal binding domain 2 pseudogene KIAA1443 14q11.2 KIAA1443 LOC90673 BCL2L2 14q11.2-q12 BCL2-like 2 PABPN1 14q11.2-q13 poly(A) binding protein, nuclear 1 SLC22A17 14q11.2 solute carrier family 22 (organic cation transporter), member 17 EFS 14q11.2-q12 embryonal Fyn-associated substrate IL17E 14q11.2 interleukin 17E CKLFSF5 14q11.2 chemokine-like factor super family 5 MYH6 14q11.2 myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) MYH7 14q11.2 myosin, heavy polypeptide 7, cardiac muscle, beta C14orf120 14q11.2 chromosome 14 open reading frame 120 ZFHX2 14q11.2 zinc finger homeobox 2 ZNF409 14q11.2 zinc finger protein 409 THTPA 14q11.2 thiamine triphosphatase AP1G2 14q11.2 adaptor-related protein complex 1, gamma 2 subunit JPHL1 14q11 junctophilin like 1 LOC387974 14 LOC387974 DHRS2 14q11.2 dehydrogenase/reductase (SDR family) member 2 BRD7P 14q11.2 bromodomain containing 7 pseudogene LOC390462 14 similar to peroxisomal short-chain alcohol dehydrogenase; NADP-dependent retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase DHRS4 14q11.2-14q21.3 dehydrogenase/reductase (SDR family) member 4 DHRS4L2 14 dehydrogenase/reductase (SDR family) member 4 like 2 LOC387975 14 similar to peroxisomal short-chain alcohol dehydrogenase; NADP-dependent retinol dehydrogenase; NADPH-dependent retinol dehydrogenase/reductase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1709 31.5 300 - 2006 16685466
    9 - 1692 29.9 280 - 2006 16685466
    - - - 27.3 - - 2010 20547751
  • also called HEP27T
  • truncated protein beginning at Ser24
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver,pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal 24 AAs are both sufficient and necessary to direct mitochondrial import of DHRS2
  • isoforms Precursor preprotein contains an N-terminal mitochondrial targeting signal that is cleaved following mitochondrial import, resulting in mitochondrial matrix accumulation of mature Hep27
    HOMOLOGY
    Homologene
    FAMILY
  • short chain dehydrogenase/reductase (SDR) family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • a fraction of the mitochondrial DHRS2 translocates to the nucleus, where it binds to MDM2
  • mitochondrial matrix protein
  • minor fraction located within the nucleus must be translocated from the mitochondria to the nucleus
  • basic FUNCTION
  • may be inhibiting cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol
  • functions as a dicarbonyl reductase in enzymatic inactivation of reactive carbonyls, involved in covalent modification of cellular components
  • having a protective role against apoptosis induced by oxidative stress
  • has a functional role in promoting growth inhibition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    unique MYB-DHRS2-MDM2-TP53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MDM2 stabilizes TP53
  • cell & other
    REGULATION
    Other regulated at the transcriptional level by the proto-oncogene MYB and is required for MYB-induced TP53 stabilization
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS