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FLASH GENE
Symbol DHRS2 contributors: mct - updated : 10-11-2010
HGNC name dehydrogenase/reductase (SDR family) member 2
HGNC id 18349
Location 14q11.2      Physical location : 24.105.572 - 24.114.846
Synonym name
  • short chain dehydrogenase/reductase family 25C, member 1
  • dicarbonyl reductase HEP27
  • protein D
  • Synonym symbol(s) HEP27, SDR25C1
    EC.number 1.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 9.28 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    alternative promoter
    Binding site
    text structure
  • binding sites for ETS and OCT1
  • two alternative promoters: one hepatocyte specific and a second active in monocyte derived dendritic cells
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1709 31.5 300 - 2006 16685466
    9 - 1692 29.9 280 - 2006 16685466
    - - - 27.3 - - 2010 20547751
  • also called HEP27T
  • truncated protein beginning at Ser24
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas    
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver,pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal 24 AAs are both sufficient and necessary to direct mitochondrial import of DHRS2
  • isoforms Precursor preprotein contains an N-terminal mitochondrial targeting signal that is cleaved following mitochondrial import, resulting in mitochondrial matrix accumulation of mature Hep27
    HOMOLOGY
    Homologene
    FAMILY
  • short chain dehydrogenase/reductase (SDR) family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • a fraction of the mitochondrial DHRS2 translocates to the nucleus, where it binds to MDM2
  • mitochondrial matrix protein
  • minor fraction located within the nucleus must be translocated from the mitochondria to the nucleus
  • basic FUNCTION
  • may be inhibiting cell replication either by catalyzing the oxidation of estrogen and androgen or by converting cortisone in cortisol
  • functions as a dicarbonyl reductase in enzymatic inactivation of reactive carbonyls, involved in covalent modification of cellular components
  • having a protective role against apoptosis induced by oxidative stress
  • has a functional role in promoting growth inhibition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    unique MYB-DHRS2-MDM2-TP53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MDM2 stabilizes TP53
  • cell & other
    REGULATION
    Other regulated at the transcriptional level by the proto-oncogene MYB and is required for MYB-induced TP53 stabilization
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS