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FLASH GENE
Symbol DHPS contributors: mct/npt - updated : 13-03-2019
HGNC name deoxyhypusine synthase
HGNC id 2869
Corresponding disease
DHPSD deoxyhypusine synthase deficiency
Location 19p13.13      Physical location : 12.786.533 - 12.792.677
Synonym name migration-inducing gene 13
Synonym symbol(s) MIG13, DHS, DS,
EC.number 2.5.1.46
DNA
TYPE functioning gene
STRUCTURE 6.14 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ZNF44 16p11 zinc finger protein 44 (KOX 7) LOC147837 19p13.2 similar to Kruppel-type zinc finger (C2H2) ZNF442 19p13.13 zinc finger protein 442 LOC388510 19 LOC388510 LOC90576 19p13.2 hypothetical protein LOC90576 ZNF443 19p13.13 zinc finger protein 443 FLJ38281 19p13.2 hypothetical protein FLJ38281 MGC26914 19p13.2 hypothetical protein MGC26914 PGK1P2 6p21-p12 phosphoglycerate kinase 1, pseudogene 2 ZNF490 19p13.2 zinc finger protein 490 FLJ90396 19p13.2 hypothetical protein FLJ90396 MGC4238 19p13.2 hypothetical protein MGC4238 LOC284393 19p13.2 similar to 60S ribosomal protein L10 (QM protein homolog) MAN2B1 19p13.2-p13.1 mannosidase, alpha, class 2B, member 1 PTD008 19p13.2 PTD008 protein DHPS 19p13.12-p13.11 deoxyhypusine synthase MGC10870 19p13.2 hypothetical protein MGC10870 TNPO2 19p13.2 transportin 2 (importin 3, karyopherin beta 2b) MGC2803 19p13.2 hypothetical protein MGC2803 ASNA1 19q13.3 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) VMD2L1 19p13.2-p13.12 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) HOOK2 19p13.2 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) RNASEH2A 19p13.2 ribonuclease H2, large subunit JUNB 19p13.2 jun B proto-oncogene PRDX2 13q12 peroxiredoxin 2 RTBDN 19p12 retbindin DNASE2 19p13.2 deoxyribonuclease II, lysosomal KLF1 19p13.13-p13.12 Kruppel-like factor 1 (erythroid) GCDH 19p13.2 glutaryl-Coenzyme A dehydrogenase FARSLA 19p13.2 phenylalanine-tRNA synthetase-like, alpha subunit CALR 19p13.3-p13.2 calreticulin RAD23A 19p13.2 RAD23 homolog A (S. cerevisiae) PLINP-1 19p13.2 papillomavirus L2 interacting nuclear protein 1 FLJ38607 19p13.2 hypothetical protein FLJ38607 LOC339375 19p13.13 hypothetical LOC339375 NFIX 19p13.2 nuclear factor I/X (CCAAT-binding transcription factor)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1351 - 369 - 1996 8615810
includes exon 7 and alternative exon 8a
8 - 1210 - 322 - 1996 8615810
lacks exon 7 but includes alternative exon 8b
8 - 1183 - 313 - 1996 8615810
lacks exon 7 and includes alternative exon 8a
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY
  • deoxyhypusine synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • deoxyhypusine synthase, required for the post-translational formation of hypusine an unusual amino acid formed lysine from by modification of a specific residue in eucaryotic initiation factor 5A (EI5FA)
  • playing a pivotal role in cell proliferation
  • EIF5A protein and DHPS modification are essential for eukaryotic cell proliferation (Park 2006)
  • DHPS promotes early cytokine-induced inflammation in the pancreatic beta cells
  • WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3 prime untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation
  • catalyzes the crucial hypusine modification of the factor EIF5A, which promotes the translation of a subset of mRNAs involved in cytokine responses
  • functions as a tetramer to catalyze the initial step, transferring the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue (Lys50 in human EIF5A) of EIF5A, thereby forming the intermediate deoxyhypusine residue
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NAD+
  • protein
  • hypusination by DHPS is required for the ongoing production of proteins, particularly DDIT3, in response to ER stress in the beta cell
  • role for DHPS (and hypusinated EIF5A) in cellular stress responses
  • essential nature of both EIF5A and DHPS in mammalian development
  • role for DHPS in promoting T cell proliferation and differentiation via regulation of IL2RA
  • hypusine modification in EIF5A is crucial for homeostasis in mammals
  • DHPS-mediated hypusine-modification of EIF5A facilitated the translation of RHOA, resulting in the activation of the RHOA signaling pathway and leading to not only increased cell motility, and also increased tumor growth
  • DHPS catalyzes the hypusination of EIF5A using the butylamine moiety of spermidine via NAD-dependent oxidative reaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DHPSD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dhps-null mice are embryonic lethal