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FLASH GENE
Symbol DHCR24 contributors: mlc/ - updated : 10-04-2007
HGNC name 24-dehydrocholesterol reductase
HGNC id 2859
Corresponding disease
DSMS desmosterolosis
Location 1p32.3      Physical location : 55.315.299 - 55.352.921
Synonym name
  • seladin (SELective Alzheimer's Disease INdicator-1) 1
  • 3 beta-hydroxysterol delta 24 reductase
  • diminuto/dwarf1 homolog
  • desmosterol-to-cholesterol enzyme
  • Synonym symbol(s) KIAA0018, SELAD1, SELADIN1, DCE, Nbla03646
    EC.number 1.3.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 37.62 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PODN 1p32.3 podocan SLC1A7 1p33 solute carrier family 1 (glutamate transporter), member 7 CPT2 1p32 carnitine palmitoyltransferase II FLJ20580 1p32.3 hypothetical protein FLJ20580 MAGOH 1p34-p33 mago-nashi homolog, proliferation-associated (Drosophila) LRP8 1p34 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor FLJ40434 1p32.3 hypothetical protein FLJ40434 DMRTB1 1p33 DMRT-like family B with proline-rich C-terminal, 1 FLJ36155 1p32.3 likely ortholog of mouse Gli-similar 1 Kruppel-like zinc finger (Glis1) FLJ10407 1p32.3 hypothetical protein FLJ10407 DJ167A19.1 1p33-p32.1 hypothetical protein DJ167A19.1 DIO1 1p32-p33 deiodinase, iodothyronine, type I LOC51668 1p32.1-p33 HSPCO34 protein MGC8974 1p33-p32.1 hypothetical protein MGC8974 LOC388632 1 similar to heterogeneous nuclear ribonucleoprotein A3 LOC388633 1 similar to Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330) C1orf8 1p36-p31 chromosome 1 open reading frame 8 FLJ32112 1p32.3 hypothetical protein FLJ32112 LOC343190 LOC200008 1p32.3 hypothetical protein LOC200008 MRPL37 1p32.1 mitochondrial ribosomal protein L37 SSBP3 1p31.3 single stranded DNA binding protein 3 LOC391041 1 hypothetical gene supported by BC004945 THEA 1p31.3 thioesterase, adipose associated MGC27169  hyporthetical protein MGC27169 TTC4 1p31.3 tetratricopeptide repeat domain 4 DKFZp727A071 1p32.2 similar to tRNA synthetase class II FLJ20619 1p32.3 hypothetical protein FLJ20619 FLJ40201 1p32.3 hypothetical protein FLJ40201 DHCR24 1p32 24-dehydrocholesterol reductase LOC199964 1p32.3 hypothetical protein LOC199964 BSND 1p31 hypothetical protein LOC199964 PCSK9 1p32.3 proprotein convertase subtilisin/kexin type 9 USP24 1p32.2-p31.2 ubiquitin specific protease 24 LOC388634 1 similar to Ubiquitin carboxyl-terminal hydrolase 24 (Ubiquitin thiolesterase 24) (Ubiquitin-specific processing protease 24) (Deubiquitinating enzyme 24) LOC388635 1 LOC388635 LOC391042 1 similar to glycogenin LOC391043 1 similar to Aspartate aminotransferase, mitochondrial precursor (Transaminase A) (Glutamate oxaloacetate transaminase-2) LOC127406 1p32.2 similar to 33K laminin receptor homolog - bovine PPAP2B 1pter-p22.1 phosphatidic acid phosphatase type 2B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 4286 - 516 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestine    
     liver    
    Endocrineadrenal gland   highly
    Nervousbrainforebraincerebral cortex highly
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver lowly, placenta, stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • FAD binding domain
  • leader sequence
  • four possible transmembrane sequences
  • an oxidoreductase domain
  • HOMOLOGY
    interspecies homolog to C.elegans diminuto/DWARF1
    homolog to Arabidopis DWF1/DIM
    homolog to murine Dhcr24
    homolog to rattus LOC298298
    Homologene
    FAMILY
  • FAD-binding oxidoreductase/transferase type 4 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text concentrated in the nucleus after oxidative challenge
    basic FUNCTION
  • catalyzing the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis
  • acting as an antiapoptotic factor in neurons
  • playing a role in protection of cells against amyloid beta peptide toxicity and oxidative stress
  • might be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth
  • being a key mediator of Ras-induced senescence
  • regulates responses to oncogenic and oxidative stimuli
  • flavin adenine dinucleotide-dependent oxidoreductase regulating responses to oncogenic and oxidative stimuli
  • playing a role in cholesterol biosynthesis, APP processing and Abeta generation
  • CELLULAR PROCESS cell life, antiapoptosis
    cell life, senescence
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • FAD
  • protein
  • binding to TP53, displacing E3 ubiquitin ligase resulting in TP53 accumulation
  • binding independently to E3 ubiquitin ligase
  • cell & other
    REGULATION
    Other modulated by the ACTH/cAMP-driven pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) DSMS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    downregulated in large pyramidal neurons in Alzheimer's disease associated with the hyperphosphorylation of tau protein
    tumoral     --over  
    overexpressed in adrenocortical adenomas and adrenal cancer cells
    constitutional somatic mutation      
    missense mutations in desmosterolosis
    tumoral     --over  
    in mucinous cystadenocarcinomas and serous cystadenocarcinomas of the ovary
    Susceptibility Alzheimer's disease
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    pharmacological enhancement of its activity may be a novel Abeta-lowering approach for the treatment of Alzheimer disease
    ANIMAL & CELL MODELS