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FLASH GENE
Symbol DGKZ contributors: mct - updated : 05-12-2011
HGNC name diacylglycerol kinase, zeta 104kDa
HGNC id 2857
Location 11p11.2      Physical location : 46.354.738 - 46.402.104
Synonym name
  • DAG kinase zeta
  • diglyceride kinase zeta
  • Synonym symbol(s) DAGK5, DGK-zeta, DAGK6
    EC.number 2.7.1.107
    DNA
    TYPE functioning gene
    STRUCTURE 47.65 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 4094 124 1117 - 1997 9159104
    31 - 3659 103.9 929 - 1997 9159104
    31 - 3824 105.9 945 - 1997 9159104
    - - 3393 100.5 895 - 1997 9159104
    31 - 3560 - 933 - 1997 9159104
    31 - 3674 - 934 - 1997 9159104
    30 - 3590 - 906 - 1997 9159104
    31 - 3656 - 928 - 1997 9159104
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal phorboesters/diacylglycerol binding (C1 domain) with zinc fingers structure
  • a DAG catalytic domain
  • an ATP binding site
  • four ankyrin repeats near the C terminus
  • a nuclear localization site (NLS) in a region of homology with the phosphorylation site of MARCKS
  • only nuclear form that contains a nuclear localization signal
  • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacylglycerol kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • translocated to plasma membrane after stimulation
  • DGKZ export from nucleus to cytoplasm is regulated by a leucine-rich nuclear export signal through the exportin CRM1
  • basic FUNCTION
  • regulating the nuclear level of diacylglycerol
  • may act as a downstream effector of RB1 to regulate nuclear levels of diacylglycerol and phosphatidic acid
  • suppresses cardiac hypertrophy and fibrosis and prevents impaired left ventricular systolic function caused by pressure overload
  • upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells
  • induced in activated microglia in brain trauma, suggesting the functional significance of DGKzeta in this process
  • predominant DGK isoform in myocytes
  • DGKZ and TCR engagement activate signaling in both MTOR complexes 1 and 2 through the activation of the Ras-Mek1/2-Erk1/2-AP-1 pathway
  • is involved in IQGAP1/RAC1-mediated phagocytosis upon lipopolysaccharide (LPS) stimulation in macrophages
  • crucial role in IQGAP1-mediated RAC1 activation during the process of LPS-activated phagocytosis of bacteria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • within the cardiomyocyte, there exists a PPAR-DGK signalling axis that underpins the ability of PPAR ligands to inhibit EDN1-dependent hypertrophy
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • DGKzeta, but not DGKalpha or DGK, interacts with RB1
  • SNX27 is a partner of DGKZ, a negative regulator of T cell function that metabolises diacylglycerol to yield phosphatidic acid
  • IQGAP1 is a novel DGKZ-associating partner
  • cell & other
    REGULATION
    activated by ligands of PPARG (troglitazone) or PPARA (fenofibrate) and was accompanied by increased DGK activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS