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FLASH GENE

Symbol

DGKZ

contributors: mct - updated : 05-12-2011

HGNC name	diacylglycerol kinase, zeta 104kDa
HGNC id	2857

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p11.2      Physical location : 46.354.738 - 46.402.104
Synonym name	DAG kinase zeta
	diglyceride kinase zeta
Synonym symbol(s)	DAGK5, DGK-zeta, DAGK6
EC.number	2.7.1.107

DNA

TYPE	functioning gene
STRUCTURE	47.65 kb     31 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001105540 32 - 4094 124 1117 - 1997 9159104 NM_003646 31 - 3659 103.9 929 - 1997 9159104 NM_201532 31 - 3824 105.9 945 - 1997 9159104 variant 3 - - 3393 100.5 895 - 1997 9159104 NM_201533 31 - 3560 - 933 - 1997 9159104 NM_001199266 31 - 3674 - 934 - 1997 9159104 NM_001199268 30 - 3590 - 906 - 1997 9159104 NM_001199267 31 - 3656 - 928 - 1997 9159104

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N terminal phorboesters/diacylglycerol binding (C1 domain) with zinc fingers structure
	a DAG catalytic domain
	an ATP binding site
	four ankyrin repeats near the C terminus
	a nuclear localization site (NLS) in a region of homology with the phosphorylation site of MARCKS
	only nuclear form that contains a nuclear localization signal

HOMOLOGY

Homologene

FAMILY

eukaryotic diacylglycerol kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	translocated to plasma membrane after stimulation
	DGKZ export from nucleus to cytoplasm is regulated by a leucine-rich nuclear export signal through the exportin CRM1

basic FUNCTION	regulating the nuclear level of diacylglycerol
	may act as a downstream effector of RB1 to regulate nuclear levels of diacylglycerol and phosphatidic acid
	suppresses cardiac hypertrophy and fibrosis and prevents impaired left ventricular systolic function caused by pressure overload
	upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells
	induced in activated microglia in brain trauma, suggesting the functional significance of DGKzeta in this process
	predominant DGK isoform in myocytes
	DGKZ and TCR engagement activate signaling in both MTOR complexes 1 and 2 through the activation of the Ras-Mek1/2-Erk1/2-AP-1 pathway
	is involved in IQGAP1/RAC1-mediated phagocytosis upon lipopolysaccharide (LPS) stimulation in macrophages
	crucial role in IQGAP1-mediated RAC1 activation during the process of LPS-activated phagocytosis of bacteria

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

within the cardiomyocyte, there exists a PPAR-DGK signalling axis that underpins the ability of PPAR ligands to inhibit EDN1-dependent hypertrophy

a component

INTERACTION

DNA

RNA

small molecule
	ATP

protein	DGKzeta, but not DGKalpha or DGK, interacts with RB1
	SNX27 is a partner of DGKZ, a negative regulator of T cell function that metabolises diacylglycerol to yield phosphatidic acid
	IQGAP1 is a novel DGKZ-associating partner

cell & other

REGULATION

activated by

ligands of PPARG (troglitazone) or PPARA (fenofibrate) and was accompanied by increased DGK activity

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS