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FLASH GENE
Symbol DGKI contributors: mct/npt - updated : 08/12/2008
HGNC name diacylglycerol kinase, iota
HGNC id 2855
Location 7q33      Physical location : 137.074.385 - 137.531.609
Synonym name DAG kinase iota
Synonym symbol(s) DGK-IOTA
EC.number 2.7.1.107
DNA
TYPE functioning gene
STRUCTURE 457.22 kb     34 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
34 - 4780 117 1065 - Bowne (2000)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two cysteine-rich repeats
  • protein kinase conserved region 1 C1
  • a conserved DAG catalytic domain
  • a DAG accessory domain
  • a four ankyrin repeats at its C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • may play a crucial role in the production of phosphatidic acid in the retina
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may attenuate protein kinase activity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS