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FLASH GENE
Symbol DGKB contributors: mct/npt - updated : 08/12/2008
HGNC name diacylglycerol kinase, beta 90kDa
HGNC id 2850
Location 7p22.2      Physical location : 14.184.674 - 14.881.075
Synonym name
  • DAG kinase beta
  • diglyceride kinase beta
    • Synonym symbol(s) KIAA0718, DAGK2, DGK, DGK-BETA
    EC.number 2.7.1.107
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 693.64 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    CROT 7q21.1 carnitine O-octanoyltransferase GTF2IRD2 7q11.23 transcription factor GTF2IRD2 LOC389465 7 hypothetical gene supported by BT009862; NM_003142 ABCB4 7q21.1 ATP-binding cassette, sub-family B (MDR/TAP), member 4 LOC392725 7 similar to Cohesin subunit SA-3 (Stromal antigen 3) (SCC3 homolog 3) PMS2L5 7q11-q22 postmeiotic segregation increased 2-like 5 ABCB1 7q21.1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 SCIN 7p21.3 scinderin LOC392726 7 LOC392726 ARL4 7p21-p15.3 ADP-ribosylation factor-like 4 RPIB9 7q21.13 Rap2-binding protein 9 MCFP 7q21.13 mitochondrial carrier family protein ASK 7q21.3 mitochondrial carrier family protein ADAM22 7q21.1 a disintegrin and metalloproteinase domain 22 PPP1R3A 7q11.23 protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle) SRI 7q21.1 sorcin FLJ23153 7q21.13 likely ortholog of mouse tumor necrosis-alpha-induced adipose-related protein LOC392869 7 similar to 60S ribosomal protein L26 ETV1 7p22 ets variant gene 1 LOC392948 7 similar to CSRP2 binding protein isoform a; CRP2 binding protein; cysteine rich protein 2 binding protein; CRP2 binding partner LOC392949 7 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) FOXP2 7q31 forkhead box P2 LOC392950 7 similar to elongation factor 1 alpha DGKB 7p22.2 diacylglycerol kinase, beta 90kDa FLJ32110 7q21.13-q21.2 hypothetical protein FLJ32110 LOC221808 7p21.3 similar to 60S ribosomal protein L26 MGC26647 7q21.13 hypothetical protein MGC26647 ETV1 7p22 ets variant gene 1 DGKB 7p22.2 diacylglycerol kinase, beta 90kDa HIC 7q31.1 diacylglycerol kinase, beta 90kDa LOC392636 7 similar to RIKEN cDNA A530016O06 gene TFEC 7q31.2 transcription factor EC LOC392745 7 similar to Six transmembrane epithelial antigen of prostate MEOX2 7p21 mesenchyme homeo box 2 (growth arrest-specific homeo box) STEAP2 7q21 six transmembrane epithelial antigen of prostate 2 LOC389466 7 LOC389466 FLJ21062 7q21.2 hypothetical protein FLJ21062 LOC221813 7p21.3 similar to RIKEN cDNA A530016O06 gene LOC85865 7q21.2 hypothetical protein BC004923 CLDN12 7q21 claudin 12 TES 7q31.2 testis derived transcript (3 LIM domains) MEOX2 7p21 mesenchyme homeo box 2 (growth arrest-specific homeo box) CAV2 7q31.1-q31.2 caveolin 2 PFTK1 7q21-q13 PFTAIRE protein kinase 1 CAV1 7q31.2-q31.3 caveolin 1, caveolae protein, 22kDa
    RNA
    TRANSCRIPTS type messenger
    text several isoforms differing by alternative splicing and the usage of different polyadenylation signals
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3926 90 804 - Caricasole (2002)
    - - 3172 87 772 - Caricasole (2002)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
     nerve   highly
    Reproductivefemale systemuterus   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal EF hand calcium-binding domains
  • two phorbol esters/diacylglycerol binding domain (C1 domain)
  • a DAG catalytic domain
  • a DAG accessory domain
  • cysteine-rich zinc finger like (? LIM domain) and putative ATP-binding sites
    • HOMOLOGY
    interspecies homolog to rattus diacylglycerol
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text one variant to cytoplasm, the other to plasma membrane
    basic FUNCTION
  • key enzymes in lipid metabolism that function to reintroduce diacylglycerol formed from the hydrolysis of phospholipids into the biosynthetic pathway
  • invoved in phosphorylation of long chain diacetylglycerols
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Ca2+
  • ATP
    • protein
    cell & other
    REGULATION
    activated by stimulated phosphatidylserine
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in Wilms tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS