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FLASH GENE
Symbol DGKA contributors: mct/npt - updated : 30-01-2009
HGNC name diacylglycerol kinase, alpha 80kDa
HGNC id 2849
Location 12q13.2      Physical location : 56.324.945 - 56.347.805
Synonym name
  • DAG kinase alpha
  • diglyceride kinase alpha
  • Synonym symbol(s) DAGK, DAGK1, DGK-alpha, MGC12821, MGC42356
    EC.number 2.7.1.107
    DNA
    TYPE functioning gene
    STRUCTURE 22.86 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D1S1221E - DGKA - D12S53E - D12S1388E - qter
    Physical map
    LOC121129 12q13.13 similar to seven transmembrane helix receptor LOC390329 12 similar to seven transmembrane helix receptor LOC121130 12q13.13 similar to seven transmembrane helix receptor PSMB3P 12q12 proteasome (prosome, macropain) subunit, beta type, 3 pseudogene MGC17301 12q13.13 hypothetical protein MGC17301 ITGA7 12q13.3 integrin, alpha 7 GCN5L1 12q13-q14 GCN5 general control of amino-acid synthesis 5-like 1 (yeast) RDH5 12q13-q14 retinol dehydrogenase 5 (11-cis and 9-cis) CD63 12q12-q13 CD63 antigen (melanoma 1 antigen) GDF11 12q12 growth differentiation factor 11 CIP29 12q13.13 cytokine induced protein 29 kDa ORMDL2 12q12 ORM1-like 2 (S. cerevisiae) DNAJ 12q13.13 DnaJ protein MMP19 12q14 matrix metalloproteinase 19 PYM 12q13.13 PYM protein DGKA 12q13.3 diacylglycerol kinase, alpha 80kDa SILV 12q13-q14 silver homolog (mouse) CDK2 12q13.3 cyclin-dependent kinase 2 SUOX RAB5B 12q13 RAB5B, member RAS oncogene family ZNFN1A4 12q13 zinc finger protein, subfamily 1A, 4 (Eos) RPS26 12q14 ribosomal protein S26 ERBB3 12q13.3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PA2G4 12q13 proliferation-associated 2G4, 38kDa RPL41 12q14 ribosomal protein L41 FLJ14451 12q13.13 hypothetical protein FLJ14451 MBC2 12q13.13 hypothetical protein FLJ14451 MLC1SA 12q13.13 hypothetical protein FLJ14451 MYL6 12q12 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle SMARCC2 12q13-q14 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 RNF41 12q13.13 ring finger protein 41 MGC2731 12q13.13 hypothetical protein MGC2731 SLC39A5 12q13.3 solute carrier family 39 (metal ion transporter), member 5 FLJ34236 12q13.13 hypothetical protein FLJ34236 FLJ32452 12q13.13 hypothetical protein FLJ32452
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2, 3 and 4 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 2756 - 735 - Merino (2007)
    24 - 2801 - 735 - Merino (2007)
    25 - 2769 - 735 - Merino (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Lymphoid/Immunespleen   highly
     thymus   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Nervousglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal EF hand calcium-binding domains
  • two phorbol esters/diacylglycerol binding domain (C1 domain)
  • a DAG catalytic domain
  • a DAG accessory domain
  • existence of additional domains that confer specific plasma membrane localization (Merino 2007)
  • at least two cysteine-rich motifs of unknown function
  • a conserved C-terminal domain, essential for membrane binding in a phosphatidic acid-dependent manner (Merino 2007)
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • protein kinase C activator
  • regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes (Alonso 2005)
  • phosphorylates diacylglycerol to phosphatidic acid, modifying the cellular levels of these two lipid mediators (Merino 2007)
  • acting as a negative modulator of diacylglycerol-based signals during T cell activation (Merino 2007)
  • playing a role on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes (Alonso 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    Other modulating (phosphorylated) protein kinase C
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS