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FLASH GENE
Symbol DGKA contributors: mct/npt - updated : 30-01-2009
HGNC name diacylglycerol kinase, alpha 80kDa
HGNC id 2849
Location 12q13.2      Physical location : 56.324.945 - 56.347.805
Synonym name
  • DAG kinase alpha
  • diglyceride kinase alpha
    • Synonym symbol(s) DAGK, DAGK1, DGK-alpha, MGC12821, MGC42356
    EC.number 2.7.1.107
    DNA
    TYPE functioning gene
    STRUCTURE 22.86 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D1S1221E - DGKA - D12S53E - D12S1388E - qter
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2, 3 and 4 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 2756 - 735 - Merino (2007)
    24 - 2801 - 735 - Merino (2007)
    25 - 2769 - 735 - Merino (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth   highly
    Lymphoid/Immunespleen   highly
     thymus   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    Nervousglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two N terminal EF hand calcium-binding domains
  • two phorbol esters/diacylglycerol binding domain (C1 domain)
  • a DAG catalytic domain
  • a DAG accessory domain
  • existence of additional domains that confer specific plasma membrane localization (Merino 2007)
  • at least two cysteine-rich motifs of unknown function
  • a conserved C-terminal domain, essential for membrane binding in a phosphatidic acid-dependent manner (Merino 2007)
    • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • protein kinase C activator
  • regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes (Alonso 2005)
  • phosphorylates diacylglycerol to phosphatidic acid, modifying the cellular levels of these two lipid mediators (Merino 2007)
  • acting as a negative modulator of diacylglycerol-based signals during T cell activation (Merino 2007)
  • playing a role on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes (Alonso 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    Other modulating (phosphorylated) protein kinase C
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS