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FLASH GENE
Symbol DET1 contributors: mct/npt - updated : 13/11/2008
HGNC name de-etiolated homolog 1 (Arabidopsis)
HGNC id 25477
Location 15q25.3      Physical location : 89.055.713 - 89.089.912
Synonym name de-etiolated-1 homolog
Synonym symbol(s) FLJ10103, MGC126156, MGC126157
DNA
TYPE functioning gene
STRUCTURE 34.20 kb     6 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2343 65 561 - Wertz (2004)
- - 2273 - 550 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Lymphoid/Immunespleen   moderately
Reproductivefemale systemplacenta  moderately
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscular   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text moderately in placenta and highly in umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to rattus Det1 (99 pc)
homolog to murine Det1 (99.6 pc)
Homologene
FAMILY
  • DET1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for ubiquitination and subsequent degradation of target proteins
  • involved in JUN ubiquitination and degradation
  • modulating Cul4A functions by a novel mechanism
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism protein
    signaling
    ubiquitin-dependent protein catabolism
    a component
  • component of the E3 ubiquitin ligase DCX DET1-COP1 complex
  • forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 associated 1), and a member of the UBE2E group of canonical ubiquitin-conjugating enzymes (Pick 2007)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS