protein
| MTOR-interacting protein, that normally functions to inhibit the MTORC1 and MTORC2 pathways |
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interacts with a C-terminal portion of MTOR (AA1483 |
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2000) that is upstream of its kinase domain and does not encompass the mLST8/G |
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L binding site (AA 2001 |
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2549) |
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inhibitor of the MTOR kinase that is highly regulated at the posttranslational level |
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CRTC2 modulated negatively by interaction with DEPTOR and positively by the TSC1-TSC2 protein complex |
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BTRC regulates cell growth and autophagy by controlling the ubiquitination and destruction of DEPTOR, an endogenous mammalian target of rapamycin inhibitor, in a phosphorylation-dependent manner |
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through DEPTOR stabilization, AMBRA1 establishes a feedback loop that ensures the rapid onset of autophagy by enhancing MTOR inactivation |
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inhibitor of MTOR and CRTC2 |
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CUL1 promoted MTOR activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR |
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RNF7 is an E3 ligase that promotes ubiquitylation and degradation of PHLPP1 and DEPTOR, leading to activation of the PI3K/AKT/MTOR axis, whereas RNF7 knockdown caused their accumulation |