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FLASH GENE
Symbol DEPDC1 contributors: mct - updated : 19-05-2022
HGNC name DEP domain containing 1
HGNC id 22949
Location 1p31.3      Physical location : 68.939.836 - 68.962.799
Synonym name cell cycle control protein SDP35
Synonym symbol(s) DEP.8, FLJ20354, SDP35, DEPDC1A, DEPDC1-V2, 5830484J08Rik
DNA
TYPE functioning gene
STRUCTURE 22.96 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 5356 93 811 - 2021 34210956
  • isoform a
  • can form homo or heterodimer with isoform b
    • 11 - 4504 61.4 527 - 2021 34210956
  • isoform b
  • can form homo or heterodimer with isoform a
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   predominantly
    Reproductivemale systemtestis  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one DEP domain
  • one Rho-GAP domain
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Depdc1a (83.0pc)
    homolog to rattus Depdc1 (82.5pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • is localized to the centrosome in metaphase
  • predominantly localized in the nucleus during interphase and is redistributed into the whole cell upon nuclear membrane breakdown in metaphase
    • basic FUNCTION
  • playing an essential role in the growth of bladder cancer cells
  • may be involved in intracellular signaling cascade, as a GTPase activator
  • plays a pivotal role in the regulation of proper mitotic progression
  • required for the integrity of centrosome and organization of the bipolar spindle
  • novel role for DEPDC1 in maintaining centrosome integrity during mitosis for the accurate distribution of chromosomes
  • plays an oncogenic role in lung adenocarcinoma (LUAD)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder carcinoma
    tumoral     --over  
    at both mRNA and protein levels innasopharyngeal carcinoma (NPC) tissues compared with normal or non-tumor tissues
    tumoral     --over  
    in Colorectal cancer (CRC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may act as a potential biomarker for CRC detection as well as a prognostic predictor concerning the survival of CRC patient
    • Therapy target
    SystemTypeDisorderPubmed
    cancerhead and neck 
    may serve as a novel therapeutic target in NPC
    cancerreproductiveprostate
    might be a potential therapeutic target against prostate carcinoma
    ANIMAL & CELL MODELS