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FLASH GENE
Symbol DENND6A contributors: mct - updated : 25-01-2017
HGNC name DENN domain containing 6A
HGNC id 26635
Location 3p14.3      Physical location : -
Synonym name
  • FAM116A protein
  • hypothetical protein LOC201627
  • family with sequence similarity 116, member A
  • Synonym symbol(s) FLJ34969, FAM116A, AFI1A,
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 67.62 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4679 - 608 - 2011 21330364
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
     thyroid   highly
    Hearing/Equilibriumearinnercochlea  
    Lymphoid/Immunethymus    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine A630054L15Rik
    Homologene
    FAMILY
  • FAM116 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • DENND6A and AVL9 are required for cell migration
  • DENND6A, DENND6B and RAB14 therefore define an endocytic recycling pathway needed for ADAM protease trafficking and regulation of cell-cell junctions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS