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FLASH GENE
Symbol DEK contributors: mct/pgu - updated : 07-04-2010
HGNC name DEK oncogene
HGNC id 2768
Corresponding disease
DEK myelodysplastic syndrome, refractory anemia with excess of blasts in transformation (MDS/RAEBT)
Location 6p22.3      Physical location : 18.224.399 - 18.264.799
Synonym name
  • DEK oncogene (DNA binding)
  • protein DEK
    • Synonym symbol(s) D6S231E
    DNA
    TYPE functioning gene
    STRUCTURE 40.40 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC391871 6 similar to malate dehydrogenase 1; malate dehydrogenase, soluble; Malate dehydrogenase-like enzyme MYLIP 6p23-p22.3 myosin regulatory light chain interacting protein MRPL42P2 6p22.3 myosin regulatory light chain interacting protein GMPR 6p23 guanosine monophosphate reductase SCA1 6p23 spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1) RNPC6 6p22.3 RNA-binding region (RNP1, RRM) containing 6 CAP2 6p22.3 CAP, adenylate cyclase-associated protein, 2 (yeast) FAM8A1 6p23 family with sequence similarity 8, member A1 NUP153 6p25.3-p22.1 nucleoporin 153kDa KIF13A 6p23 kinesin family member 13A NHLRC1 6p22.3 NHL repeat containing 1 TPMT 6p22.3 thiopurine S-methyltransferase AOF1 6p22.3 amine oxidase, flavin containing 1 DEK 6p23 DEK oncogene (DNA binding) LOC391872 6 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) LOC391873 6 similar to inosine monophosphate dehydrogenase 1 isoform b; sWSS2608 IBRDC2 6p22.3 IBR domain containing 2 LOC346129 6p22.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) ID4 6p23-p22.3 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein LOC391874 6 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) OACT1 6p22.3 O-acyltransferase (membrane bound) domain containing 1 E2F3 6q22 E2F transcription factor 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2785 - 341 - 2010 20040570
    11 - 2879 43 375 - 2010 20040570
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveesophagus   predominantly
     intestinelarge intestinecolon moderately
     intestinesmall intestine  moderately
     salivary gland   highly
    Endocrinethyroid   moderately
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunethymus   moderately
    Reproductivefemale systemuteruscervix highly
     male systemprostate  moderately
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • a SAP putative DNA binding domain
  • an acidic domain interacting with histone
  • central and C-terminal regions are highly conserved
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Dek (92.5 pc)
    ortholog to murine Dek (91.4 pc)
    Homologene
    FAMILY
  • DNA-binding SAP family
    • CATEGORY chaperone/stress , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • playing a role in viral genome replication
  • inducing positive supercoils into closed circular DNA
  • being also involved in splice site selection during mRNA processing
  • nuclear phosphoprotein implicated in oncogenesis and autoimmunity
  • promotes the repair of DNA lesions and protects cells from genotoxic agents that typically trigger poly(ADP-ribose) polymerase activation
  • crucial role of poly(ADP-ribosyl)ation in shaping DEK autoantigenic properties and in its function as a promoter of cell survival
  • may be a histone chaperone
  • promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells
  • required for intron removal
  • exerting a potent inhibitory effect on both EP300 and PCAF-mediated histone acetyltransferase activity and transcription
  • playing a role in the proliferation of hematopoietic cells
  • DEK-NUP214 fusion protein appears defective, at least in part, in assisting transcriptional regulation of certain genes that might be essential for normal differentiation of hematopoietic cells
  • suppresses cellular senescence, apoptosis, and differentiation, thus promoting cell growth and survival in monolayer and organotypic epithelial raft models
  • important for DNA double-strand break repair
    • CELLULAR PROCESS nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and THOC4
    • INTERACTION
    DNA binding to cruciform and superhelical DNA
    RNA binding
    small molecule nucleotide,
  • GTP
    • protein
  • histones H2A, H2B, H3, H4, acetylated histone H4
  • non-phosporylated DAXX
  • HDAC2
  • interacting wth SET and PARP1 (constitute a network governing access to chromatin by the transcription machinery)
  • molecular links between DEK and DNA damage response signaling pathways, suggesting that DEK contributes to DNA repair
    • cell & other
  • the (pets) site of the HIV2 enhancer, autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEK
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    tumoral     --over  
    in many solid tumors such as colon cancer, larynx cancer, bladder cancer, and melanoma
    tumoral fusion translocation    
    t(6;9) chromosomal translocation associated with a subtype of acute myelogenous leukemia (AML), which results in the formation of a DEK-NUP214 fusion protein
    tumoral     --over gain of function
    in retinoblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • detection of DEK protein expression should be useful for the diagnosis and prognosis of ovarian serous cancer
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyataxia 
    able to partially reverse the mutation-prone phenotype of cells from patients with ataxia telangiectasia
    cancerreproductiveovary
    might be a useful molecular target for ovarian cancer therapy
    cancer  
    targeted suppression of DEK may become a strategic approach to the treatment of cancer
    ANIMAL & CELL MODELS