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FLASH GENE
Symbol DEGS1 contributors: mct - updated : 27-10-2012
HGNC name degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
HGNC id 13709
Location 1q42.12      Physical location : 224.370.927 - 224.381.140
Synonym name
  • dihydroceramide desaturase
  • sphingolipid delta 4 desaturase
  • Synonym symbol(s) MLD, DES1, MGC5079, DEGS
    DNA
    TYPE functioning gene
    STRUCTURE 9.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 2101 37 323 - 2002 11937514
    - splicing 1681 37 323 - 2002 11937514
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    three histidine containing consensus motifs
    HOMOLOGY
    interspecies homolog to Drosophila melanogaster des-1
    Homologene
    FAMILY spingolipid delta 4 desaturase fgamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • inserting double bonds at delta 4 position in fatty acids
  • involvement in cell cycle progression in human neuroblastoma cells
  • enzyme responsible for generating ceramide from its precursor dihydroceramide and thus controling synthesis of the bioactive lipid ceramide
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other oxidative stress leads to potent inhibition of dihydroceramide desaturase resulting in significant elevation in dihydroceramide levels
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS