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FLASH GENE
Symbol DEFB105B contributors: KTN/npt - updated : 26-01-2009
HGNC name defensin, beta 105B
HGNC id 29930
Location 8p23.1      Physical location : 7.345.242 - 7.681.360
Synonym name beta-defensin 5
Synonym symbol(s) BD-5, DB5, DEFB-5, DEFB105
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, opposite orientation, tail to tail
text
  • duplication resulting in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation
  • representing the more telomeric copy
  • STRUCTURE 1.83 kb     3 Exon(s)    2 Copie(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D8S1819 - D8S1706 - DEFB105B - D8S1825 - D8S503 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 237 - 78 - -
  • a 27 aa signal peptide of 3.1 kda
  • a 51 aa mature peptide of 5.8 kda
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Defb12 (68 pc)
    homolog to murine Defb12 (66.7 pc)
    Homologene
    FAMILY
  • beta-defensin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as an antibacterial factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS