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FLASH GENE
Symbol DEFB104B contributors: KTN/npt - updated : 26-01-2009
HGNC name defensin, beta 104B
HGNC id 26165
Location 8p23.1      Physical location : 7.327.830 - 7.698.763
Synonym name beta-defensin 4
Synonym symbol(s) BD-4, DEFB-4, DEFB104
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, head to head, opposite orientation
text
  • duplication resulting in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation
  • representing the more telomeric copy
  • STRUCTURE 4.77 kb     2 Exon(s)    2 Copie(s)
    regulatory sequence Binding site   transcription factor
    text structure
  • several AP-1 and GATA1 binding sites (García 2001)
  • MAPPING cloned Y linked N status provisional
    Map pter - D8S1819 - D8S1706 - DEFB104B - D8S1825 - D8S516 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 281 - 72 - -
  • a 22 aa signal peptide of 2.6 kda
  • a 50 aa mature peptide of 6 kda
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 22 aa signal peptide
  • six-cysteine motif characteristic for a ß-defensin (García 2001)
  • HOMOLOGY
    Homologene
    FAMILY
  • beta-defensin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having antimicrobial and chemoattractant activities (García 2001)
  • having synergistic effects with lysozyme and DEFB103 (García 2001)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by PKC (protein kinase C) mediation in airway epithelial cells (García 2001)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS