| basic FUNCTION
| involved in oxygen independent phagocytosis of Gram+, Gram- bacteria, many fungi, some viruses, in phagocyte-mediated host defense with ERCC6 to coordinate repair and RNA POL2 proteolysis in response to DNA damage |
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contributing to the anti-HIV1 activity of CD8 antiviral factor |
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can potentially suppress hepatic glucose production through an intracellular mechanism distinct from the classical insulin signaling pathway  |
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its activation requires proteolytic excision of its anionic N-terminal inhibitory pro peptide (pro peptide of proDEFA1 also interacts specifically with and inhibits the antimicrobial activity of DEFA1 inter-molecularly) |
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DEFA1 and DEFB1 promoted the up-regulation of CD91 on the dendritic cells surface |
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mediates host immune responses to tumors through the recruitment and subsequent activation of immature dendritic cells |
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contribute to innate immunity through diverse actions, including microbial killing |
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with DEFB1, inactivated both X4 and R5 HIV-1 |
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induce interleukin IL8 in airway epithelial cells |
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play different roles in the pathogenesis ofidiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and diffuse panbronchiolitis (DPB), according to the location in the lung where the alpha-defensins are mainly produced |
