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FLASH GENE
Symbol DEF6 contributors: mct - updated : 06-04-2013
HGNC name differentially expressed in FDCP 6 homolog (mouse)
HGNC id 2760
Location 6p21.31      Physical location : 35.265.594 - 35.289.546
Synonym name
  • IRF4-binding protein
  • defensin, alpha 6
  • Synonym symbol(s) IBP, DEFA6, SLAT
    DNA
    TYPE functioning gene
    STRUCTURE 23.95 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2320 74 631 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a pleckstrin homology domain (PH)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • its localization, a Rho-family guanine nucleotide exchange factor, to the center of the immune synapse is dependent upon ITK
  • in addition to its role as a GEF, DEF6 may also function in regulating mRNA translation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ITK controlled the central localization of DEF6, which may contribute to the activation of CDC42 at the center of the interface (PMId: 21971040)
  • ITK both interacts with DEF6 and phosphorylates DEF6 at tyrosine residues Tyr(210) and Tyr(222)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS