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FLASH GENE
Symbol DEDD2 contributors: npt/ - updated : 28-10-2005
HGNC name death effector domain containing 2
HGNC id 24450
Location 19q13.2      Physical location : 42.702.751 - 42.721.813
Synonym name
  • death effector domain-containing DNA binding protein 2
  • DED-containing protein FLAME-3
  • FADD-like anti-apoptotic molecule 3
  • Synonym symbol(s) FLAME-3, FLAME3
    DNA
    TYPE functioning gene
    STRUCTURE 19.06 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CEACAM5 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM6 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) CEACAM3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 3 LOC388544 19 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) MGC42718 19q13.31 hypothetical protein MGC42718 DMRTC2 19q13.31 DMRT-like family C2 RPS19 19q13.2 ribosomal protein S19 CD79A 19q13.2-q13.3 CD79A antigen (immunoglobulin-associated alpha) ARHGEF1 19q13,13 Rho guanine nucleotide exchange factor (GEF) 1 LOC390937 19 similar to Erf RABAC1 19q13.13-q13.2 Rab acceptor 1 (prenylated) ATP1A3 19q13.2 ATPase, Na+/K+ transporting, alpha 3 polypeptide GRIK5 19q13.2 glutamate receptor, ionotropic, kainate 5 FLJ22059 19q13.31 hypothetical protein FLJ22059 POU2F2 19q13.31 POU domain, class 2, transcription factor 2 DEDD2 19q13.31 POU domain, class 2, transcription factor 2 KIAA1951 GSK3A 19q13.2 glycogen synthase kinase 3 alpha ERF 19q13.1 Ets2 repressor factor CIC 19q13.2 capicua homolog (Drosophila) PAFAH1B3 19q13.1 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa MGC70924 19q13.31 hypothetical LOC284338 FLJ90805 19q13.31 hypothetical protein FLJ90805 EGFL4 19q12 EGF-like-domain, multiple 4 SBP1 19q13.31 HBV pre-s2 binding protein 1 LOC84518 19q13.31 protein related with psoriasis LIPE 19q13.1-q13.2 lipase, hormone-sensitive UNQ473 19q13.31 DMC LOC388545 19 similar to Zinc finger protein 216
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1951 36 326 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • death effector domain
  • a nuclear localization signal (NLS)
  • mono polymer homomer , heteromer
    HOMOLOGY
    Homologene
    FAMILY
  • death effector protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • important mediator for death receptors and targeting caspases to the nucleus
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text CD95 induced apoptosis
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerizing and heterodimerizing with DEDD and forming a complex with TFIIIC102
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TFIIIC102 translating
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS