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FLASH GENE
Symbol DEC1 contributors: mct - updated : 11-12-2010
HGNC name deleted in esophageal cancer 1
HGNC id 23658
Location 9q33.1      Physical location : 117.904.096 - 118.164.923
Synonym name candidate tumor suppressor CTS9
Synonym symbol(s) CTS9, DESGC1
DNA
TYPE functioning gene
STRUCTURE 260.83 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D9S262 - [D9S155 - D9S177 ] - D9S170 - D9S154 - D9S258 - qter
Text [DESGC1 ]
Physical map
WDR31 9q33.1 WD repeat domain 31 BSPRY 9q33.1 B-box and SPRY domain containing MGC12904 9q33.1 hypothetical protein MGC12904 ALAD 9q33.3 aminolevulinate, delta-, dehydratase POLE3 9q33 polymerase (DNA directed), epsilon 3 (p17 subunit) C9orf43 9q33.1 chromosome 9 open reading frame 43 RGS3 9q31-q33 regulator of G-protein signalling 3 FLJ31713 9q33.1 hypothetical protein FLJ31713 LOC392385 9 similar to programmed cell death 2 isoform 1; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog KIAA1952 9q33.1 KIAA1952 protein AMBP 9q32-q33 alpha-1-microglobulin/bikunin precursor KIF12 9q33.1 kinesin family member 12 COL27A1 9q33.1 collagen, type XXVII, alpha 1 ORM1 9q32 orosomucoid 1 ORM2 9q32 orosomucoid 2 AKNA 9q32 AT-hook transcription factor AKNA CIP98 9q33.1 CASK-interacting protein CIP98 ATP6V1G1 9q33.1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1 DKFZp547P234 9q33.1 DKFZp547P234 protein LOC389786 9 LOC389786 TNFSF15 9q32 tumor necrosis factor (ligand) superfamily, member 15 LOC392386 9 similar to serine/threonine-protein kinase PRP4K; serine/threonine-protein kinase PRP4 homolog TNFSF8 9q33 tumor necrosis factor (ligand) superfamily, member 8 TNC 9q33.3 tenascin C (hexabrachion) DEC1 9q32 tenascin C (hexabrachion) C9orf27 9q31.3 chromosome 9 open reading frame 27 PAPPA 9q33.1 pregnancy-associated plasma protein A ASTN2 9q33.1 astrotactin 2 TRIM32 9q33.1 tripartite motif-containing 32
regionally located located in a region commonly deleted in esophageal squamous cell carcinomas
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1251 - 70 - 2005 15580306
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines esophageal squamous cell carcinomas
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • functioning as a tumor suppressor associated with esophageal cancer
  • myopepithelial cell marker, playing an important role in the process of natural suppression of tumor invasion as it is expressed specifically in myoepithelial cells, providing a cellular barrier for the spreading cancer cells
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text negative regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly reduced in esophageal squamous cell carcinoma
    tumoral     --low  
    and tends to contribute to the migration ability of Head and Neck Squamous cell lines
    Susceptibility to squamous cell carcinoma of the head and neck
    Variant & Polymorphism other functional DEC1 promoter polymorphism -249T>C reduces risk of squamous cell carcinoma of the head and neck
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS