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Symbol DDX51 contributors: mct - updated : 01-07-2008
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
HGNC id 20082
Location 12q24.33      Physical location : 132.621.141 - 132.628.880
Synonym name
  • DEAD box protein 73D-like
  • DEAD box protein 51
  • Synonym symbol(s) MGC42193, DKFZp686N2081
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 7.74 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4738 72.3 666 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryolfactory  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX51/DBP6 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having helicase, ATP binding, ATP dependent helicase activities
  • required for the formation of the 3prime end of 28S rRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • DDX51 is a ribosome synthesis factor and an interacting partner of GTPBP4
  • binds to pre-60S subunit complexes and promotes displacement of U8 snoRNA from pre-rRNA, which is necessary for the removal of the 3prime external transcribed spacer from 28S rRNA and productive downstream processing
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS