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FLASH GENE
Symbol DDX5 contributors: mct - updated : 19-10-2015
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
HGNC id 2746
Location 17q24.1      Physical location : 62.494.373 - 62.502.484
Synonym name
  • nuclear antigen 68kD
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kDa)
  • probable ATP-dependent RNA helicase DDX5
  • DEAD box-5
  • helicase, RNA, nuclear 1
  • RNA-dependent ATPase
  • Synonym symbol(s) G17P1, HELR, HLR1, P68, HUMP68, DKFZp434E109, DKFZp686J01190
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 8.11 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    Binding site   transcription factor
    text structure binding sites for Sp1, AP-2, CRE, MYC
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388410 17 LOC388410 CSH2 17q23.3-q24.2 chorionic somatomammotropin hormone 2 GH2 17q23 growth hormone 2 CSH1 17q23.3-q24.2 chorionic somatomammotropin hormone 1 (placental lactogen) CSHL1 17q23.3-q24.2 chorionic somatomammotropin hormone-like 1 GH1 17q24 growth hormone 1 CD79B 17q23 CD79B antigen (immunoglobulin-associated beta) SCN4A 17q23 sodium channel, voltage-gated, type IV, alpha ICAM2 17q23-q25 intercellular adhesion molecule 2 ERN1 16p12 ER to nucleus signalling 1 FLJ30999 17q24.2 hypothetical protein FLJ30999 HT008 17q24.2 uncharacterized hypothalamus protein HT008 LOC253013 17q24.2 similar to ribosomal protein L31 PECAM1 17q23 platelet/endothelial cell adhesion molecule (CD31 antigen) LOC284021 17q24.2 hypothetical protein LOC284021 POLG2 17q polymerase (DNA directed), gamma 2, accessory subunit DDX5 17q21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 LOC90799 17q24.2 hypothetical protein BC009518 SMURF2 17q22-q23 hypothetical protein BC009518 LOC388411 17 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) LOC390807 17 hypothetical gene supported by AK097700 MGC40489 17q24 hypothetical protein MGC40489 LOC388412 17 LOC388412 KIAA0563 17q24.2 LOC388412 LOC390808 17 similar to solute carrier family 16, member 6; monocarboxylate transporter 6 LOC284020 17q24.2 similar to solute carrier family 16, member 6; monocarboxylate transporter 6 FLJ32065 17q24.2 hypothetical protein FLJ32065 GNA13 17q24 guanine nucleotide binding protein (G protein), alpha 13
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3769 - 614 - 1990 2349099
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one helicase ATP-binding domain
  • one helicase C-terminal domain
  • conjugated PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Ddx5 (99.2pc)
    homolog to rattus Ddx5 (99.3pc)
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX5/DBP2 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • can localize to the nuclear matrix during interphase by binding AKAP95
  • basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • involved in translation initiation, nuclear and mitochondrial splicing and ribosome and spliceosome assembly
  • important transcriptional regulator, functioning as a coactivator or corepressor, depending on the context of the promoter and the transcriptional complex
  • may act as a tumor cosuppressor in governing p53 transcriptional activity
  • proliferation-associated nuclear antigen, reacting with the simian virus 40 tumor antigen
  • playing a critical role with DDX17 in promoting the assembly of proteins required for formation of the transcription initiation complex and chromatin remodeling
  • coactivator of MYOD1
  • may be involved in pre-mRNA splicing
  • may also confer apoptosis resistance by upregulation of X-chromosome-linked inhibitor apoptosis protein-associated factor 1
  • phosphorylated DDX5 protects cells from programmed cell death by preventing procaspase-8 from proteolytic cleavage
  • androgen receptor transcriptional coactivator
  • involved in multiple myeloma tumorigenesis
  • DDX5 and DDX17 have been shown to act as transcriptional co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ESR1)
  • crucial role for DDX17 in ESR1 co-activation and oestrogen-dependent cell growth and likely distinct but important roles for both DDX5 and DDX17 in regulating ESR1 activity in breast cancer
  • repressor of fibrogenic genes in hepatic stellate cells through interaction with transcriptional complexes
  • is a key TP53-independent target of the CDKN2A and is a novel non-oncogene participant in ribosome biogenesis
  • DDX5 and DDX17 have a dual role in the control of the pro-migratory NFAT5 transcription factor
  • DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation
  • RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • identified in the spliceosome C complex
  • DDX5/SRA1 stabilizes the interaction of cohesin with CTCF by binding to both, and is required for proper insulator function
  • INTERACTION
    DNA
    RNA
  • binding
  • small molecule nucleotide,
  • ATP binding
  • protein
  • substrate of TLK1 (phosphorylates immunoprecipitated DDX5)
  • phosphorylated DDX5 interacts with nuclear beta catenin and is thus involved in cell proliferation
  • interacting with fibrillarin in nascent nucleoli during late telophase
  • interacting with SARS coronavirus helicase
  • CDKN2A inhibited the interaction between DDX5 and nucleophosmin (NPM), preventing association of DDX5 with the rDNA promoter and nuclear pre-ribosomes
  • DDX5 and DDX17 act are transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration
  • ATP-dependent DEAD-box RNA helicase, is a component of the MAML1 protein complex
  • DDX5 interacts with MAML1 and is associated with the endogenous NOTCH1 transcription activation complex in human T-ALL leukemic cells
  • ARVCF interacts with different proteins involved in mRNA-processing: SRSF1 (SF2/ASF), DDX5, and HNRNPH2
  • cell & other
    REGULATION
    Other sumoylation on lys53 modulates its transcriptional activity and promotes its interaction with HDAC1
    PDGF-dependent phosphorylation by c-Abl kinase in the nyucleus
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    increased expression and polyubiquitylated in colorectal tumors, may contribute to colon cancer formation by directly upregulating proto-oncogenes
    tumoral     --over  
    overexpressed in prostate cancer with a possible role in progression to hormone refractory disease
    tumoral fusion      
    gene fused in frame with ETV4 in prostate cancer, leading to the expression of a DDX5-ETV4 fusion protein
    Susceptibility
    Variant & Polymorphism SNP
  • SNP S480A is linked to a reduced repressive function of DDX5 and thus an enhanced fibrogenic activity
  • DDX5 minor allele is associated with increased risk of developing advanced fibrosis in patients with chronic hepatitis C
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential new target for modulating the Notch signaling in leukemia
    ANIMAL & CELL MODELS