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FLASH GENE
Symbol DDX42 contributors: npt - updated : 28-04-2010
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
HGNC id 18676
Location 17q23.3      Physical location : 61.851.566 - 61.896.676
Synonym name
  • DEAD box polypeptide 42 protein
  • RNA helicase-like protein
  • SF3b125 DEAD-box protein
  • splicing factor 3B-associated 125 kDa protein
  • RNA helicase-related protein
  • SF3b125 DEAD-box protein
  • Synonym symbol(s) RHELP, RNAHP, SF3b125, FLJ43179
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 45.11 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CYB561 17q11-qter cytochrome b-561 LOC342541 17q24.1 similar to peptidyl-Pro cis trans isomerase ACE 17q23 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 KCNH6 17q24.2 potassium voltage-gated channel, subfamily H (eag-related), member 6 HAN11 17q24.2 WD-repeat protein LOC51204 17q24.2 clone HQ0477 PRO0477p LOC390806 17 similar to Hypothetical protein FLJ14668 MAP3K3 17q24.2 mitogen-activated protein kinase kinase kinase 3 MGC10986 17q24.2 hypothetical protein MGC10986 LYK5 17q24.2 protein kinase LYK5 GK001 17q24.2 GK001 protein DDX42 17q24.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 FTSJ3 17q23 FtsJ homolog 3 (E. coli) PSMC5 17q24-q25 proteasome (prosome, macropain) 26S subunit, ATPase, 5 SMARCD2 17q23-q24 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 LOC388410 17 LOC388410 CSH2 17q23.3-q24.2 chorionic somatomammotropin hormone 2 GH2 17q23 growth hormone 2 CSH1 17q23.3-q24.2 chorionic somatomammotropin hormone 1 (placental lactogen) CSHL1 17q23.3-q24.2 chorionic somatomammotropin hormone-like 1 GH1 17q24 growth hormone 1 CD79B 17q23 CD79B antigen (immunoglobulin-associated beta) SCN4A 17q23 sodium channel, voltage-gated, type IV, alpha ICAM2 17q23-q25 intercellular adhesion molecule 2 ERN1 16p12 ER to nucleus signalling 1 FLJ30999 17q24.2 hypothetical protein FLJ30999 HT008 17q24.2 uncharacterized hypothalamus protein HT008
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4014 103 938 - Olsen (2006)
    18 - 3943 103 938 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunetonsils   highly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to highly homologous to the p68 subfamily of RNA helicases
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX42 subfamily
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having nucleic acid binding, ATP dependent helicase activities
  • DEAD box protein possessing RNA helicase, protein displacement and RNA annealing activities
  • capable of modulating TP53BP2 function (Uhlmann-Schiffler 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 17S U2 snRNP splicing complex (Gustafson 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with TP53BP2, a major apoptosis inducer known to enhance TP53 transactivation of proapoptotic genes (interact via a domain within the C-terminal part of DDX42 and a mid-N-terminal sequence as well as the ankyrin-SH3 region of TP53BP2) (Uhlmann-Schiffler 2009)
  • interacting with JEV NS4A protein (Gustafson 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS