protein
| interacts specifically with hepatitis C virus core protein, resulting in a change in intracellular location |
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interacting with TDRD3 |
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interacting with the multi-component translation initiation factor eIF3 (major interaction partner) |
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interacting with TBK1 |
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interacting with EIF4E, thus repressing its translation  |
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interacting with HIV Rev protein and XPO1 |
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interacting with vaccinia virus K7 protein, thus evading the innate immunity response by preventing DDX3X from inducing IFN-beta production  |
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DDX3X is critical for translation of CCNE1 mRNA, which provides an alternative mechanism for regulating CCNE1 expression during the cell cycle  |
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required to promote the localization and chromosome segregation of NCAPH  |
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PABP1 [poly(A)-binding protein 1] is another direct interaction partner of DDX3X  |
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implicated as a scaffolding adaptor that directly facilitates phosphorylation of IRF3 by IKBKE and might thus be involved in pathway-specific activation of IRF3  |
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DDX1 and DDX3X DEAD-box RNA helicases are known to be required for efficient HIV-1 Rev-dependent RNA export  |
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DDX3X modulates cell adhesion and motility and cancer cell metastasis via RAC1-mediated signaling pathway  |
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DDX3X may participate in antiviral innate immunity, at least in part, by translational control of PRKRA  |
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DDX3 regulates epigenetic transcriptional and translational activation of TP53 and colocalizes with TP53 at centrosome during mitosis to ensure proper mitotic progression and genome stability, which supports the tumor-suppressive role of DDX3X  |
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DDX3X binds the eIF4F complex, which we found to be required for ER stress-induced ATF4 expression  |
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DDX3X inhibits expression of Kruppel-like factor 4 (KLF4), a transcription factor and cell cycle repressor  |
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DDX3X also directly interacts with CHUK and enhances its autophosphorylation and -activation  |
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MAPKs and GSK3 phosphorylate GLE1 and thereby coordinate stress granules (SGs) dynamics by altering DDX3X function  |
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DDX3X steers MITF protein levels dictating melanoma metastatic potential and response to targeted therapy  |
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DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation  |