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FLASH GENE
Symbol DDX39B contributors: mct - updated : 24-10-2014
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
HGNC id 13917
Location 6p21.33      Physical location : -
Synonym name
  • DEAD-box protein UAP56
  • HLA-B associated transcript-1
  • ATP-dependent RNA helicase p47
  • 56 kDa U2AF65-associated protein
  • nuclear RNA helicase (DEAD family)
  • 56 kDa U2AF65-associated protein
  • spliceosome RNA helicase BAT1
  • HLA-B associated transcript 1
  • Synonym symbol(s) D6S81E, UAP56, BAT1
    EC.number 3.6.4.13
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 12.23 kb     11 Exon(s)
    motif
    MAPPING cloned Y linked N status confirmed
    regionally located localized in the vicinity of alpha and beta TNF genes
    RNA
    TRANSCRIPTS type messenger
    text multiple alternatively spliced transcripts and multiple polyadenylation sites, 4.1, 1.7 and 0.9 kb (PMID: 7601445)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2133 49 428 - 1997 924249
    11 splicing 2003 49 428 - 1997 924249
  • coding the same protein than the variant 1
  • lacking 130 bases in the 5' UTR
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunethymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • very rich proline, containing a DEAD box (Asp-Glu-Ala-Asp)
  • HOMOLOGY
    interspecies homolog to rattus P47 nuclear protein
    homolog to Drosophila WM6 product
    ortholog to murine Bat1a
    intraspecies paralog to DDX39 ( 90 p100)
    Homologene
    FAMILY
  • DExD/H box family of proteins
  • ATP-dependent RNA helicases/DECD subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • ATP dependent RNA helicase, may be a translation initiation factor
  • acting as a negative regulator of inflammatory cytokines
  • DExD/H-box protein that promotes prespliceosome assembly
  • essential pre-mRNA splicing factor required for the first ATP-dependent spliceosome assembly step
  • RNA-stimulated ATPase that can only hydrolyze ATP
  • with DDX39, have essential but largely overlapping functions in the processing and export of mRNAs
  • has an essential role in mRNA nuclear export
  • regulates protein synthesis and growth in cardiomyocytes
  • mediates an ATP-dependent interaction between the THO complex and both SARNP and THOC4, indicating that TREX assembly is ATP-dependent
  • likely that it functions in remodeling TREX, and, in this case, at least two proteins, SARNP and THOC4, play roles
  • plays a pivotal role in the efficient transcription/replication of influenza A virus
  • DDX39, DDX39B play an essential role for cellular mRNA export by recruiting the adaptor protein ALYREF to spliced and unspliced mRNAs
  • ALYREF, THOC1 and DDX3
  • is an important binding partner of BCR and a novel target for inhibiting vascular smooth muscle cell proliferation
  • ALYREF, THOC1 and DDX39B form a highly integrated unit to associate with the spliced mRNA and function in mRNA export
  • is a regulator of VSMC proliferation and DDX93B is a target for preventing vascular proliferative disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    text negative regulator of inflamation
    PATHWAY
    metabolism
    signaling
    a component SARNP, THOC4, and BAT1 form an ATP-dependent trimeric complex, and BAT1 bridges the interaction between SARNP and THOC4
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacts with U2AF(65) in an ATP-dependent manner, and subsequently with U4/U6 snRNAs to facilitate stepwise assembly of the spliceosome
  • PLK1 interacts with the DExH/D RNA helicase, DDX39B
  • DDX329B/BCR interaction is important for BCR induced DNA synthesis
  • cell & other
    REGULATION
    Phosphorylated by PLK1, and PLK1-dependent phosphorylation of DDX39B triggers ubiquitination and degradation of DDX39B through proteasomes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for rheumatoid arthritis
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    BCR/DDX39B interaction may be a target for inhibiting pathological VSMC proliferation
    ANIMAL & CELL MODELS