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FLASH GENE
Symbol DDX25 contributors: mct/npt - updated : 09/12/2008
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
HGNC id 18698
Location 11q24.2      Physical location : 125.774.271 - 125.793.003
Synonym name gonadotropin-regulated testicular RNA helicase
Synonym symbol(s) GRTH
EC.number 3.6.1.-
DNA
TYPE functioning gene
STRUCTURE 18.73 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure
  • TATA-less gene with multiple transcriptional start sites (TSS), GC-rich sequences and a promoter located within -205/+63 bp of the gene
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1839 54.6 483 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbraindiencephalonhypothalamus moderately
    Reproductivemale systemtestis  predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    ReproductiveLeydig cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an helicase ATP-binding domain
  • N terminal DEAD box (Asp-Glu-Ala-Asp/His)
  • a C-terminal helicase domain
  • HOMOLOGY
    interspecies homolog to rattus Ddx25 (95.1 pc)
    homolog to murine Ddx25 (94.9 pc)
    Homologene
    FAMILY
  • DEAH subfamily
  • DEAD box helicase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • detected in both cytoplasm and nucleus of testicular cells
  • also detected in chromatoid bodies of round spermatids
  • basic FUNCTION
  • acting as an ATP-dependent RNA helicase
  • required for mRNA export and translation regulation during spermatid development
  • acting as a negative regulator of the tumor necrosis factor receptor 1 and caspase pathways
  • promoting NF-kappaB function to control apoptosis in spermatocytes
  • CELLULAR PROCESS cell life, differentiation
    protein, translation regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • translation activator
  • spermatogenesis
  • mRNA transport
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
  • binding to ATP
  • protein
  • unphosphorylated DDX25 interacts with CRM1 (Gustafson 2010)
  • cell & other
    REGULATION
    induced by chorionic gonadotropin via cyclic AMP-induced androgen formation in the Leydig cell
    Other phosphorylated on threonine residues (only found in cytoplasm)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to male infertility
    Variant & Polymorphism missense mutation associated with loss of DDX25 phosphorylation in infertile male (Tsai Morris 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    DDX25 null mice (Gutti, 2008)