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FLASH GENE
Symbol DDX21 contributors: mct/npt/pgu - updated : 07-04-2009
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
HGNC id 2744
Location 10q21.3      Physical location : 70.715.891 - 70.744.279
Synonym name
  • Gu protein
  • RNA helicase II/Gu alpha
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
  • nucleolar RNA helicase II
  • Synonym symbol(s) GUA, GURDB, RH-II/GuA, DKFZp686F211
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with DDX50
    STRUCTURE 28.39 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure no TATA box
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4153 87.2 783 - 2008 18180292
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunetonsils   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal DEAD/H box (Asp-Glu-Ala-Asp/His)
  • dsRNA helicase domain
  • C terminal domain as RNA foldase
  • HOMOLOGY
    intraspecies paralog to DDX21L
    Homologene
    FAMILY
  • DEAD box helicase family
  • DDX21/DDX50 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text
  • nucleolar retention of DDX21 is dependent on the presence of nucleostemin in the nucleolus
  • inhibition of JNK signalling results in partial delocalization of DDX21 from the nucleolus to the nucleoplasm, increased nucleolar mobility of DDX21 and inhibition of rRNA processing
  • basic FUNCTION
  • double stranded unwinding RNA and folding single stranded RNA
  • multifunctional nucleolar protein involved in ribosomal RNA processing
  • CELLULAR PROCESS nucleotide
    protein, editing
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text ribosomal RNA biogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • part of a large protein complex containing proteins related to pre-rRNA processing, such as PES1, GNL3, and EBNA1BP2, in addition to several ribosomal proteins
  • DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TICAM1 pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells (mDCs)
  • INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • interaction between JUN and DDX21 regulates nucleolar localization of DDX21
  • physically interacts with ribosomal protein L4 (RPL4), a component of 60S ribosome large subunit (its function in rRNA processing is at least partially dependent on its ability to interact with RPL4)
  • cell & other
    REGULATION
    Other regulated by JUN (supports ribosomal RNA processing and its nucleolar localization)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for watermelon stomach disease
    Marker
    Therapy target
    ANIMAL & CELL MODELS