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FLASH GENE
Symbol DDN contributors: mct - updated : 27-08-2015
HGNC name dendrin
HGNC id 24458
Location 12q13.12      Physical location : 49.388.932 - 49.393.088
Synonym name
  • KIAA0749 protein
    • Synonym symbol(s) KIAA0749
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3744 81 711 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   predominantly Homo sapiens
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two putative NLS (NLS1 and NLS2),
  • three PPXY motifs (P1, P2, and P3)
  • C-Terminus of dendrin interacts with nephrin
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • nuclear relocation of dendrin in response to glomerular injury promotes podocyte apoptosis
    • basic FUNCTION
  • a putative modulator of the postsynaptic cytoskeleton
  • slit diaphragms protein with proapoptotic signaling properties that accumulates in the podocyte nucleus in response to glomerular injury
  • acting as an enhancer of apoptosis
  • its expression during glomerulogenesis and in the normal human kidney is similar to that previously shown for nephrin, which suggests that dendrin associates with the slit diaphragm complex
  • is an important component of cytoskeletal modifications at the synapse
  • having a a surveillance function at the slit diaphragms and relocates to the podocyte nucleus in response to glomerular injury, thereby providing a signaling mechanism whereby changes in slit diaphragms function modulate podocyte survival
  • dual compartment protein with proapoptotic signaling properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the slit diaphragms complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds directly to nephrin and CD2AP, by its C-terminus
  • YAP1 binding to dendrin is a prosurvival mechanism
  • dendrin binds to WTIP and GADD45A (WTIP and GADD45A mediate gene transcription in the nucleus, suggesting that dendrin may have similar functions in podocytes
  • DDN is phosphorylated by FYN and dephosphorylated by PTPN1, and FYN-induced phosphorylation prevents NEDD4L-mediated ubiquitination of dendrin
  • MAGI2 and FYN protect DDN from NEDD4L-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI2 in podocytes results in glomerulosclerosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • relocation of dendrin to the podocyte nuclei is useful as a novel marker of podocyte injury in human glomerulopathy
    • Therapy target
    ANIMAL & CELL MODELS