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FLASH GENE
Symbol DDC contributors: mct/npt - updated : 21-04-2010
HGNC name dopa decarboxylase (aromatic L-amino acid decarboxylase)
HGNC id 2719
Corresponding disease
DDC DOPA decarboxylase deficiency
Location 7p12.1      Physical location : 50.526.135 - 50.633.154
Synonym name
  • DOPA decarboxylase
  • aromatic-L-amino-acid decarboxylase
  • Synonym symbol(s) AADC
    EC.number 4.1.1.28
    DNA
    TYPE functioning gene
    STRUCTURE 107.02 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ABP1 7q34-q36 amiloride binding protein 1 (amine oxidase (copper-containing)) KCNH2 7q35-q36 potassium voltage-gated channel, subfamily H (eag-related), member 2 GRB10 7p12-p11.2 growth factor receptor-bound protein 10 NOS3 7q36 nitric oxide synthase 3 (endothelial cell) FLJ39415 7q36.1 hypothetical protein FLJ39415 ABCB8 7q35-q36 ATP-binding cassette, sub-family B (MDR/TAP), member 8 LOC389490 7 similar to PRO0758 ACCN3 7q35 amiloride-sensitive cation channel 3, testis CDK5 7q36 cyclin-dependent kinase 5 SLC4A2 7q35-q36 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) FASTK 7q35 FAST kinase C7orf21 7q36.1 chromosome 7 open reading frame 21 CENTG3 7q36.17q36.1 centaurin, gamma 3 ZNFN1A1 7p13-p11.1 zinc finger protein, subfamily 1A, 1 (Ikaros) LOC393070 7 similar to gastrulation brain homeobox 1 ASB10 7q35 ankyrin repeat and SOCS box-containing 10 LOC392842 7 similar to hypothetical protein 4931409K22 FIGNL1 7p12.2 fidgetin-like 1 LOC392843 7 similar to hypothetical protein FLJ22527 ABCF2 7q35-q36 ATP-binding cassette, sub-family F (GCN20), member 2 DDC 7p11 dopa decarboxylase (aromatic L-amino acid decarboxylase) CSGlcA-T 7q36.1 KIAA1402 protein SMARCD3 7q35-q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 GRB10 7p12-p11.2 growth factor receptor-bound protein 10 NYREN18 7q36 growth factor receptor-bound protein 10 LOC349136 7q36.1 hypothetical protein LOC349136 COBL 7p12.1 hypothetical protein LOC349136 CRYGN 7q36.1 crystallin, gamma N
    RNA
    TRANSCRIPTS type messenger
    text variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2090 54 480 - Vassilacopoulou, Scherer (1992)
    15 - 1975 - 480 - Vassilacopoulou, Scherer (1992)
    lacking exons 10-15
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
    Respiratorylung   highly
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • pyridoxal-dependent decarboxylase conserved domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • pyridoxal-dependent aminotransferase superfamily
  • group II decarboxylase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • aromatic L-amino acid decarboxylase, required for the synthesis of dopamine and serotonine
  • pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine (Kokkinou 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DDC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    at the mRNA level, in the specimens from prostate cancer patients, in comparison to those from benign prostate hyperplasia patients (Avgeris 2008)
    Susceptibility to nicotine dependence
    Variant & Polymorphism other poymorphism increasing the risk of nicotine dependence
    Candidate gene potential of DDC expression, at the mRNA level, as a novel biomarker in prostate cancer (Avgeris 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS