basic FUNCTION
| component of the HH signaling pathway involved in the malignant transformation of squamous cell lineage |
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important component of the neddylation E3 complex that functions to recruit charged E2 and is involved in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity |
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induces extracellular matrix invasion by activating matrix metalloproteinase 2 in squamous cell carcinoma |
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involved in protein degradation |
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possible role in the pathogenesis of gliomas and other human cancers |
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has broader, pleiotropic effects that are essential for cullin neddylation |
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has an essential role in neddylation, involving nuclear localization of neddylation components and recruitment and proper positioning of UBC12 |
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DCUN1D1 expression may play a role in tumor progression and development of brain metastasis in patients with Non-small cell lung carcinoma (NSCLC) |
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DCUN1D1 functions as a substrate sensor and activator of CUL2-RING ligase |
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oncogenic activity of DCUN1D1 requires its potentiating neddylation domain, which regulates its E3 activity for neddylation |
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specific role of the DCUN1D1-UBE2M interaction for cellular neddylation of cullin 3 |