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FLASH GENE
Symbol DCTN5 contributors: mct - updated : 07-11-2017
HGNC name dynactin 5 (p25)
HGNC id 24594
Location 16p12.1      Physical location : 23.652.806 - 23.681.182
Synonym name dynactin subunit p25
Synonym symbol(s) MGC3248, p25
DNA
TYPE functioning gene
STRUCTURE 34.84 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 7359 - 152 - 2004 15043994
6 - 7329 - 182 - 2004 15043994
3 - 699 - 84 - 2004 15043994
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • contain the isoleucine-patch motif and adopt the left-handed parallel beta-helix fold
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope
    basic FUNCTION
  • involved in cilia structure and/or function
  • DCTN5, DCTN6 are peripheral components that can be removed without any obvious impact on dynactin integrity and dynactin lacking these subunits shows reduced membrane binding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    results in impaired early and recycling endosome movement, but late endosome movement is unaffected, and mitotic spindles appear normal
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS