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FLASH GENE
Symbol DCTN4 contributors: mct/npt/pgu - updated : 21-03-2009
HGNC name dynactin 4 (p62)
HGNC id 15518
Location 5q33.1      Physical location : 150.088.309 - 150.138.657
Synonym name dynactin subunit p62
DNA
TYPE functioning gene
STRUCTURE 50.35 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text five alternatively spliced transcripts altogether encoding five proteins ACR/NCBI
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3937 52 460 - 2000 10671518
14 - 3958 53 467 - 2000 10671518
13 - 4105 45.6 403 - 2000 10671518
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   predominantly
Nervousbrain   highly
Respiratorylung   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Zn2+ RING finger domain, cysteine rich
  • HOMOLOGY
    Homologene
    FAMILY
  • dynactin subunit 4 family
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • punctate cytoplasmic and centrosomal distribution
  • targeted to the nucleus when overexpressed
  • basic FUNCTION
  • required for cytoplasmic movement of vesicles and organelles along microtubules
  • could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin
  • to the cortical cytoskeleton
  • collaborates with dystrophin in coordinating costamere-aligned microtubules
  • CELLULAR PROCESS cell cycle, division
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of a large (20s) macromelecular complex (ARP1 pointed end side) required for the cytoplasmic dynein-driven movement of organelles along the microtubules
  • ATP7B interaction with p62 is a key component of the copper-induced trafficking pathway that delivers ATP7B to subapical vesicles of hepatocytes for the removal of excess copper into bile
  • member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to ARP1 (ACTR1A, ACTR1B)
  • interacting with ATP7B (key component of the copper-induced trafficking pathway that delivers ATP7B to subapical vesicles of hepatocytes for the removal of excess copper into bile), interaction required copper, the metal-binding CXXC motifs, and the region between MBS 4 and MBS 6 of ATP7B
  • interacting with ANK2 (ANK2 is required for the costamere localization of DCTN4 and is a candidate to mediate interactions of DCTN4 with membrane cargo as well as to stabilize the fast-growing ends of specialized microtubules associated with costameres)
  • ANK2 binds to dystrophin, DCTN4, and microtubules and is required for sarcolemmal association of these proteins as well as dystroglycan
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS