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FLASH GENE

Symbol

DCTN4

contributors: mct/npt/pgu - updated : 21-03-2009

HGNC name	dynactin 4 (p62)
HGNC id	15518

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q33.1      Physical location : 150.088.309 - 150.138.657
Synonym name	dynactin subunit p62

DNA

TYPE	functioning gene
STRUCTURE	50.35 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	five alternatively spliced transcripts altogether encoding five proteins ACR/NCBI

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016221 13 - 3937 52 460 - 2000 10671518 NM_001135643 14 - 3958 53 467 - 2000 10671518 NM_001135644 13 - 4105 45.6 403 - 2000 10671518

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       predominantly Nervous brain       highly Respiratory lung       highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a Zn2+ RING finger domain, cysteine rich

HOMOLOGY

Homologene

FAMILY

dynactin subunit 4 family

CATEGORY

motor/contractile , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	punctate cytoplasmic and centrosomal distribution
	targeted to the nucleus when overexpressed

basic FUNCTION	required for cytoplasmic movement of vesicles and organelles along microtubules
	could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin
	to the cortical cytoskeleton
	collaborates with dystrophin in coordinating costamere-aligned microtubules

CELLULAR PROCESS	cell cycle, division
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component	component of a large (20s) macromelecular complex (ARP1 pointed end side) required for the cytoplasmic dynein-driven movement of organelles along the microtubules
	ATP7B interaction with p62 is a key component of the copper-induced trafficking pathway that delivers ATP7B to subapical vesicles of hepatocytes for the removal of excess copper into bile
	member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10

INTERACTION

DNA

RNA

small molecule

protein	binding directly to ARP1 (ACTR1A, ACTR1B)
	interacting with ATP7B (key component of the copper-induced trafficking pathway that delivers ATP7B to subapical vesicles of hepatocytes for the removal of excess copper into bile), interaction required copper, the metal-binding CXXC motifs, and the region between MBS 4 and MBS 6 of ATP7B
	interacting with ANK2 (ANK2 is required for the costamere localization of DCTN4 and is a candidate to mediate interactions of DCTN4 with membrane cargo as well as to stabilize the fast-growing ends of specialized microtubules associated with costameres)
	ANK2 binds to dystrophin, DCTN4, and microtubules and is required for sarcolemmal association of these proteins as well as dystroglycan

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS