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FLASH GENE
Symbol DCTN2 contributors: mct - updated : 09-05-2012
HGNC name dynactin 2 (p50)
HGNC id 2712
Location 12q13.3      Physical location : 57.924.093 - 57.940.978
Synonym name
  • dynamitin
  • 50 kDa dynein-associated polypeptide
  • p50 dynamitin
  • Synonym symbol(s) RPB50, DCTN50, DYNAMITIN, gmp23-48k
    DNA
    TYPE functioning gene
    STRUCTURE 16.88 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SHMT2 12q13.2 serine hydroxymethyltransferase 2 (mitochondrial) NXPH4 12q13.2 neurexophilin 4 LOC56901 12q13.2 NADH:ubiquinone oxidoreductase MLRQ subunit homolog MGC2793 12q13.2 hypothetical protein MGC2793 KIAA1002 12q13.2 Homo sapiens KIAA1002 protein (KIAA1002), mRNA. LOC338803 12q13.2 similar to RIKEN cDNA 1300003K24 INHBC 12q13.1 inhibin, beta C INHBE 12q13.2 inhibin, beta E GLI 12q13.3-q14.1 glioma-associated oncogene homolog (zinc finger protein) ARHGAP9 12q14 Rho GTPase activating protein 9 MARS 12q13.11-q14.3 methionine-tRNA synthetase DDIT3 12q13.1-q13.2 DNA-damage-inducible transcript 3 MBD6 12q13.2 methyl-CpG binding domain protein 6 DCTN2 12q13.2-q13.3 dynactin 2 (p50) KIF5A 12q13 kinesin family member 5A PIP5K2C 12q13.2 phosphatidylinositol-4-phosphate 5-kinase, type II, gamma FLJ34766 GEFT 12q13.2 RAC/CDC42 exchange factor SLC26A10 12q13 solute carrier family 26, member 10 GALGT 12q13.3 UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase (GalNAc-T) LOC390333 12 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein OS-9 12q13 amplified in osteosarcoma CENTG1 12q13.3 centaurin, gamma 1 SAS 12q13-q14 sarcoma amplified sequence CDK4 12q14 cyclin-dependent kinase 4 LOC92979 12q13.2 hypothetical protein BC009489 CYP27B1 12q13-q14 cytochrome P450, family 27, subfamily B, polypeptide 1 METTL1 12q13 methyltransferase-like 1 DKFZP586D0919 12q13.2 hepatocellularcarcinoma-associated antigen HCA557a TSFM 12q13-q14 Ts translation elongation factor, mitochondrial AVIL 12q13.13 advillin CTDSP2 12q13-q15 . CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 1757 45 406 - 2008 18182012
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a dimerization motif in the N-terminal 100 amino acids
  • three coiled-coil domains
  • dynactin component with the CAP-Gly domain
  • a basic leucine zipper (bZIP) domain
  • an alpha-helical motif spanning AA 106-162
  • C-terminal half of the molecule (AA 213-406), which is predicted to fold into an antiparallel alpha-helix bundle
  • HOMOLOGY
    Homologene
    FAMILY
  • dynactin subunit 2 family
  • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text recruited to kinetochore during prometaphase, concentrating near spindle poles there after
    basic FUNCTION
  • playing an essential role in growth cone advance by interaction with DCTN1
  • could transport and target microtubule fragments to the plus ends of growing microtubules in the growth cone
  • CEP135 and DCTN2 play an important role in assembly and maintenance of functional microtubule-organizing centers
  • not a major role for DCTN2 overexpression in carcinogenesis
  • essential for the survival of sensory neurons and the maintenance of ganglion cell axons, and functions as a major determinant of apicobasal polarity in retinal radial glia
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    text chromosome and spindle organization
    PATHWAY
    metabolism
    signaling
    transporting NUMA1 for the formation of mitotic spindle poles
    a component
  • component of the large macromolecular complex, dynactin, required for the cytoplasmic dynein-driven movement of organelles along microtubules, core element of dynactin structure
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+/calmodulin
  • protein
  • cytoplasmic dynein
  • dinein
  • MARCKS regulated by PKRC and Ca2+/calmodulin, involved in cell spreading
  • interacting with DCTN1
  • interaction partners of CEP135, the 50 kDa subunit of the dynactin complex (DCTN2) and CEP250, have their binding sites in the C-terminal domain of CEP135
  • cell & other
  • microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS