Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DCTN2 contributors: mct - updated : 09-05-2012
HGNC name dynactin 2 (p50)
HGNC id 2712
Location 12q13.3      Physical location : 57.924.093 - 57.940.978
Synonym name
  • dynamitin
  • 50 kDa dynein-associated polypeptide
  • p50 dynamitin
    • Synonym symbol(s) RPB50, DCTN50, DYNAMITIN, gmp23-48k
    DNA
    TYPE functioning gene
    STRUCTURE 16.88 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 1757 45 406 - 2008 18182012
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a dimerization motif in the N-terminal 100 amino acids
  • three coiled-coil domains
  • dynactin component with the CAP-Gly domain
  • a basic leucine zipper (bZIP) domain
  • an alpha-helical motif spanning AA 106-162
  • C-terminal half of the molecule (AA 213-406), which is predicted to fold into an antiparallel alpha-helix bundle
    • HOMOLOGY
    Homologene
    FAMILY
  • dynactin subunit 2 family
    • CATEGORY motor/contractile , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text recruited to kinetochore during prometaphase, concentrating near spindle poles there after
    basic FUNCTION
  • playing an essential role in growth cone advance by interaction with DCTN1
  • could transport and target microtubule fragments to the plus ends of growing microtubules in the growth cone
  • CEP135 and DCTN2 play an important role in assembly and maintenance of functional microtubule-organizing centers
  • not a major role for DCTN2 overexpression in carcinogenesis
  • essential for the survival of sensory neurons and the maintenance of ganglion cell axons, and functions as a major determinant of apicobasal polarity in retinal radial glia
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    text chromosome and spindle organization
    PATHWAY
    metabolism
    signaling
    transporting NUMA1 for the formation of mitotic spindle poles
    a component
  • component of the large macromolecular complex, dynactin, required for the cytoplasmic dynein-driven movement of organelles along microtubules, core element of dynactin structure
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+/calmodulin
    • protein
  • cytoplasmic dynein
  • dinein
  • MARCKS regulated by PKRC and Ca2+/calmodulin, involved in cell spreading
  • interacting with DCTN1
  • interaction partners of CEP135, the 50 kDa subunit of the dynactin complex (DCTN2) and CEP250, have their binding sites in the C-terminal domain of CEP135
    • cell & other
  • microtubules
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS